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Thromb Haemost 1975; 33(03): 444-456
DOI: 10.1055/s-0038-1647838
National Conference on Thrombosis and Hemostasis, Dallas, Texas, 20.—22. November 1974
Schattauer GmbH

The Role of Blood and Platelets in Atherosclerosis and the Complications of Atherosclerosis[*]

J. F Mustard
1   Department of Pathology, McMaster University, Hamilton, Ontario
2   Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
,
M. A Packham
1   Department of Pathology, McMaster University, Hamilton, Ontario
2   Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Received 14 February 1975

accepted 14 February 1975

Publication Date:
02 July 2018 (online)

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Summary

There appear to be at least three ways in which the blood, and particularly the platelets, may contribute to the development of atherosclerosis and its complications :

1. In the mechanism causing endothelial injury and the response of the smooth muscle cells to vessel injury.

2. Through the formation of persistent mural thrombi which are organized into intimai thickenings.

3. Through the formation of thrombi in association with advanced atherosclerosis that may be either (a) mural thrombi which fragment and shower the distal circulation with platelet emboli or (b) occlusive thrombi.

* Presented at the National Conference on Thrombosis and Hemostatis, under the auspices of the Council on Thrombosis of the American Heart Association, Dallas, Texas, November 1974.


 

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