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Thromb Haemost 1975; 33(02): 335-340
DOI: 10.1055/s-0038-1647885
Original Article
Schattauer GmbH

Heterogeneity of Rabbit Platelets

IV. Thrombocytosis with Absolute Megathrombocytosis in Phenylhydrazine-induced Hemolytic Anemia in Rabbits
Michael L Freedman
1   Department of Medicine, New York University Medical School, 550 First Avenue, New York, NY 10016
,
Simon Karpatkin
1   Department of Medicine, New York University Medical School, 550 First Avenue, New York, NY 10016
› Author Affiliations
Further Information

Publication History

Received 22 October 1974

Accepted 02 January 1975

Publication Date:
02 July 2018 (online)

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Summary

Intravenous injection of Phenylhydrazine into intact rabbits resulted in a thrombocytosis of 1.85 fold and megathrombocytosis (large platelets) of 2.30 fold. Splenectomy markedly impaired this response. The intravenous injection of red blood cell hemo-lysates gave a response similar to that of Phenylhydrazine in both intact and splenec-tomized animals. Basal data obtained from intact and splenectomized animals; as well as kinetic data obtained following apparent splenic blockade secondary to Phenylhydrazine hemolysis revealed the presence of a splenic platelet pool with preferential splenic sequestration of megathrombocytes.

It is suggested that the thrombocytosis and absolute megathrombocytosis of hemolysis is due to splenic blockade by red blood cell hemolysate.

 

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