Thromb Haemost 1991; 65(03): 317-319
DOI: 10.1055/s-0038-1648142
Original Article
Schattauer GmbH Stuttgart

Platelets of Habitual Smokers Have Reduced Susceptibility to Aggregating Agent

L C Foo
The Institute for Medical Research, Kuala Lumpur, Malaysia
I Roshidah
The Institute for Medical Research, Kuala Lumpur, Malaysia
M B Aimy
The Institute for Medical Research, Kuala Lumpur, Malaysia
› Author Affiliations
Further Information

Publication History

Received: 26 June 1990

Accepted after revision 05 November 1990

Publication Date:
02 July 2018 (online)


Platelet aggregation to collagen, and productions of 6-ketoprostagltandin-F1-alpha and tromboxane 82 during aggregation were measured after an overnight fast, involving both food and cigarettros, in 19 clinically healthy habitual smokers (10 or more cigarettes/day) and 23 non-smokers receiving the same diet. The subjects (all males; ages == 21-30 years) were residents of a school hostel. Mean platelet aggregation was significantly lower in smokerr; than non-smokers (23.2 ohms vs 3L.5 ohmS, p < 0.005). Non-smokers had significantly higher mean concentration of 6-keto-prostaglandin-F1-alpha than smokers (109.8 pmol/1 vs 92.3 pmol/1, p < 0.05). The level of thromboxane B2 did not differ significerntly between the two groups. These observations suggest that the role of smokittg as a risk factor for ischaemic heart disease is unlikely to be related to a direct enhancement of aggregation. On the contrary, the observations seem to suggest that habitual smoking may directly reduce platelet aggregability.