Thromb Haemost 1978; 40(02): 326-334
DOI: 10.1055/s-0038-1648666
Original Article
Schattauer GmbH Stuttgart

Altered Factor VIII Complexes in Patients with Acute Respiratory Insufficiency

K Grant
The Institute of Health Research, Institutes of Medical Sciences; Departments of Medicine and Pathology, Pacific Medical Center; and Cancer Research Institute of the University of California, San Francisco, U.S.A.
,
R Rodvien
The Institute of Health Research, Institutes of Medical Sciences; Departments of Medicine and Pathology, Pacific Medical Center; and Cancer Research Institute of the University of California, San Francisco, U.S.A.
,
C H Mielke Jr
The Institute of Health Research, Institutes of Medical Sciences; Departments of Medicine and Pathology, Pacific Medical Center; and Cancer Research Institute of the University of California, San Francisco, U.S.A.
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Publikationsverlauf

Received 24. Oktober 1977

Accepted 23. Februar 1978

Publikationsdatum:
12. Juli 2018 (online)

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Summary

Acute respiratory failure is an often-fatal syndrome of multiple etiologies in which altered factor VIII may be a marker of endothelial disease. 12 women with overwhelming viral pneumonia were studied with serial factor VIII antigen, procoagulant activity, and von Willebrand’s factor assays. Antigen levels were elevated (range: 86-1644%) out of proportion to procoagulant activity (range: 35-521 % by a one-stage assay), and factor VIII antigen to activity ratios were as high as 16:1. Von Willebrand’s factor was normal but correlated best with procoagulant activity. All patients had abnormal antigen patterns on crossed immunoelectrophoresis, with increases in protein of both fast and slow mobility. These changes in factor VIII correlated with the patients’ clinical courses.