Measurement of Activated Factor VII Using Soluble Mutant Tissue Factor -Proposal for Standardization

Thromb Haemost 1994; 72(04): 649-650
DOI: 10.1055/s-0038-1648934

Letter to the Editor

Schattauer GmbH Stuttgart

Authors

Anthony R Hubbard

Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Herts., UK
Trevor W Barrowcliffe

Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Herts., UK

References
1 Morrissey JH, Macik BG, Neuenschwander PF, Comp PC. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993; 81: 734-744
2 Hubbard AR, Parr LJ. Potency estimation of activated factor VII concentrates. Thromb Haemost 1991; 65: 1160
3 Kitchen S, Malia RG, Preston FE. A comparison of methods for the measurement of activated factor VII. Thromb Haemost 1992; 68: 301-395
4 Hedner U, Ljundberg J, Lund-Hansen T. Comparison of the effect of plasma-derived and recombinant human FVIIa in vitro and in a rabbit model. Blood Coag Fibrinol 1990; 1: 145-152
5 WHO Expert Committee on Biological Standardization. Forty-third report. WHO Technical Report Series, No 840 1994