Immune Reactive Factor IX in Acquired Factor IX Deficiency^[*]

Summary

Factor IX-antibody-neutralizing material has been estimated in plasmas of patients with acquired factor IX deficiency. In patients with liver cirrhosis and patients who had been treated with L-Asparaginase the plasma neutralized an amount of antibody expected from the biological activity. In patients treated with phenprocoumon and in one patient with biliary obstruction an excess of factor IX-antibody neutralizing material was found. This inactive factor IX probably represents a precursor molecule of factor IX.

^* Supported by a grant of the “Österreichische Fonds zur Förderung der Wissenschaftlichen Forschung” (Nr. 900).

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