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Thromb Haemost 1972; 27(01): 059-062
DOI: 10.1055/s-0038-1649009
DOI: 10.1055/s-0038-1649009
Originalarbeiten — Original Articles — Travaux Originaux
Sedimentation Behavior of Fibrinogen from Normal and Bleeder Swine
This investigation was supported by grant HE 07181 from the U. S. P. H. S. Exp. Sta. Paper =£7120.
Further Information
Publication History
Publication Date:
29 June 2018 (online)
Summary
The Missouri Bleeder Swine have prolonged bleeding time, low factor VIII levels, reduced platelet adhesion, and respond to plasma and serum transfusions in a manner similar to that of patients with von Willebrand’s disease. The swine disease is thus more similar to von Willebrand’s disease than to classical hemophilia. The present work demonstrates that the sedimentation behavior of fibrinogen from these bleeder swine is like that of normal swine and does not show the anomalous sedimentation pattern of fibrinogen from classical hemophiliacs.
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References
- 1 Blombäck B, Blombäck M, Lauren T. C, Perrso H. Anomalous behavior of hemophilia A fibrinogen during ultracentrifugation. Biochim. biophys. Acta (Amst.) 97: 171-173. 1965;
- 2 Mertz E. T. The anomalie of a normal Duke’s and a very prolonged saline bleeding time in swine suffering from an inherited bleeding disease. Amer. J. Physiol 136: 360-363. 1942;
- 3 Boqart R, Muhrer M. E. Inheritance of a hemophilia like condition in swine. J. Heredity 33: 59-64. 1942;
- 4 Cornell G. N, Muhrer M. E. Coagulation factors in normal and hemophiliac-type swine. Amer. J. Physiol 206: 926-928. 1964;
- 5 Cooper R. G, Cornell G. N, Muhrer M. E, Garb S. Platelet adhesion in bleeder swine measured by glass bead column. Tex. Rep. Biol. Med 27: 955-961. 1969;
- 6 Cornell C. N, Cooper R. G, Kahn R. A, Garb S. Platelet adhesiveness in normal and bleeder swine as measured in a celite system. Amer. J. Physiol 216: 1170-1175. 1969;
- 7 Kahn R. A, Cooper R. G, Cornell C. N, Muhrer M. E. Electron microscopy of bleeder swine platelets. Amer. J. Yet. Res 31: 679-684. 1970;
- 8 Muhrer M. E, Lechler E, Cornell C. N, Kirkland J. L. Antihemophilic factor levels in bleeder swine following infusions of plasma and serum. Amer. J. Physiol 208: 508-510. 1965;
- 9 Biggs R, Matthews J. M. The treatment of hemorrhage in von Willebrand’s disease and the blood level of factor VIII (AHG). Brit. J. Hemat 09: 203-214. 1963;
- 10 Zimmerman T. S, Ratnoff O. D, Powell A. E. Immunological differentiation of classic hemophilia (factor VIII deficiency) and von Willebrand’s disease with some observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor. J. clin. Invest 50: 244-254. 1971;
- 11 Blombäck B, Blombäch M. Purification of human and bovine fibrinogen. Arkiv Kemi 12: 415-443. 1958;
- 12 Ware A. G, Guest M. M, Seegers W. H. Fibrinogen: with special reference to its preparation and certain properties of the product. Arch. Biochem 13: 231-236. 1947;
- 13 Spaet T. H, Kinsell B. G. Properties of bovine antihemophilic factor. Proc. Soc. exp. Biol. (N.Y.) 84: 314-317. 1953;
- 14 Brinkhous K. M, Morrison Jr. F. G, Muhrer M. E. Comparative study of clotting defects in human, canine, and porcine hemophilia. Fed. Proc 11: 409 1952;