Sedimentation Behavior of Fibrinogen from Normal and Bleeder Swine

R. G Cooper; C. N Cornell; M. E Muhrer; K Leimer

doi:10.1055/s-0038-1649009

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 27(01): 059-062
DOI: 10.1055/s-0038-1649009

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Sedimentation Behavior of Fibrinogen from Normal and Bleeder Swine

R. G Cooper

¹Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201

,

C. N Cornell

¹Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201

,

M. E Muhrer

¹Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201

,

K Leimer

¹Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201

› Author Affiliations

Abstract

Summary

The Missouri Bleeder Swine have prolonged bleeding time, low factor VIII levels, reduced platelet adhesion, and respond to plasma and serum transfusions in a manner similar to that of patients with von Willebrand’s disease. The swine disease is thus more similar to von Willebrand’s disease than to classical hemophilia. The present work demonstrates that the sedimentation behavior of fibrinogen from these bleeder swine is like that of normal swine and does not show the anomalous sedimentation pattern of fibrinogen from classical hemophiliacs.

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References

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