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DOI: 10.1055/s-0038-1649097
A Controlled Trial of Aspirin in Childhood Glomerular Disorders
Publication History
Received for publication
12 June 1973
Accepted for publication
06 July 1973
Publication Date:
24 July 2018 (online)
Summary
A controlled, prospective, double-blind study of the effect of aspirin on the clinical course and renal function of 36 children with proliferative glomerulonephritis or the nephrotic syndrome was undertaken. Despite unequivocal evidence of suppression of platelet aggregation with aspirin treatment, there were no statistically significant changes in the clinical course or any of the laboratory parameters denoting activity of the chronic glomerular renal disorder. It would appear, therefore, that additional factors besides local platelet aggregation must be involved in the perpetuation of chronic childhood renal disease.
* Reprint address: CWT, Department of Pediatrics, Harbor General Hospital, UCLA School of Medicine, 1000 West Carson Street, Torrance, California 90509.
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