Summary
To evaluate the association of plasma protein C levels with constitutional, socioeconomic,
life-style and biochemical factors important in cardiovascular diseases, we measured
protein C levels in 12,290 middle aged (45-64 years) subjects participating in the
ARIC study. Protein C levels had a normal distribution with a mean value of 3.17 fig/ml.
They were higher in women than men and in whites than blacks; higher in postmenopausal
women and further increased by hormonal supplements. The age influence was inconsistent
and was considered to be inconsequential. Protein C levels were positively correlated
with body mass index, LDL-cholesterol, HDL-cholesterol, and triglycerides and negatively
associated with cigarette smoking. These factors should be taken into consideration
when establishing normal protein C levels and when analyzing the relation between
protein C and arterial and venous thrombotic disorders.