Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1995; 74(03): 987-989DOI: 10.1055/s-0038-1649860 Scientific and Standarolzation Committee Communications Schattauer GmbH Stuttgart Comparison of Six Commercial Plasma References for Factor VIII, Factor IX and von Willebrand FactorOn behalf of the Subcommittee for Factor VIII and IX of the Scientific and Standardization Committee of the ISTHAuthors Author Affiliations Carol K Kasper 1 The Orthopaedic Hospital University of Southern California, Los Angeles, California, USA David L Aronson 2 The George Washington University Medical Center, Washington D.C., USA George Davignon 3 The University of California, San Diego, California, USA Paul Foster 4 The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA Carol Hillman-Wiseman 5 The Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan Jeanne M Lusher 5 The Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan Marilyn Manco-Johnson 6 The University of Colorado Health Sciences Center, Denver, Colorado,USA James B Meade 7 The University of North Carolina Hospitals, Chapel Hill, North Carolina, USA Robert R Montgomery 4 The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA Frederick R Rickies 8 The University of Connecticut Health Center, Farmington, Connecticut, USA Gilbert C White II 7 The University of North Carolina Hospitals, Chapel Hill, North Carolina, USA Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Summary Six brands of normal reference plasma produced in the United States, with assigned assay values for factor VIII and IX and, in four instances, ristocetin cofactor and von Willebrand antigen, were assayed in nine coagulation laboratories in academic institutions in the same country. Differences in mean assays of reference plasmas, as a percent of labelled potency, were significant and were greater than differences among laboratories. Standard methods of assigning potency to commercial reference plasmas are recommended. PDF (184 kb) References References 1 Barrowcliffe TW, Kirkwood TB L. Standardization of factor VIII. 1. Calibration of British Standards for factor VIII clotting activity Br J Haematol 1980; 46: 471-481 2 Kirkwood TB L, Barrowcliffe TW. Standardization of factor VIII. 2. A British standard for factor VIII related antigen Br J Haematol 1980; 46: 483-490 3 Barrowcliffe TW, Tydeman MA, Kirkwood TB L, Thomas DP. Standardization of factor VIII. III. Establishment of a stable reference plasma for factor VHI-related activities Thromb Haemost 1983; 50: 690-696 4 WHO Technical Report Series. 1983; 687: 23-24 5 WHO Technical Report Series. 1989; 786: 20-21 6 Heath AB, Barrowcliffe TW. Standardization of factor VIII. V. Calibration of the 2nd Inlcrnalional Standard for factor VIII and von Willebrand factor activities in plasma Thromb Haemost 1992; 68: 155-159 7 WHO Technical Report Series. 1994; 840: 7-8 8 Gabra GS, Prowsc CV, Boulton FE. Importance of a quality assurance scheme for factor VIII assays in quality monitoring of human plasma destined for fractionation into factor VIII concentrate. Vox Sang 1989; 56: 65-70
