Alterations in Vascular Endothelial Cell-related Plasma Proteins In Thalassaemic Patients and their Correlation with Clinical Symptoms

P Butthep; A Bunyaratvej; Y Funahara; H Kitaguchi; S Fucharoen; S Sato; N Bhamarapravati

doi:10.1055/s-0038-1649879

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(04): 1045-1049
DOI: 10.1055/s-0038-1649879

Original Article

Clinical Studies

Schattauer GmbH Stuttgart

Alterations in Vascular Endothelial Cell-related Plasma Proteins In Thalassaemic Patients and their Correlation with Clinical Symptoms

Authors

P Butthep

¹The Blood Disease Research Unit, Sirikit Medical Centre, Bangkok, Japan
A Bunyaratvej

²The Department of Pathology, Faculty of Medicine, Rhamathibodi Hospital, Bangkok, Japan
Y Funahara

⁵The First Department of Physiology, Kobe University School of Medicine, Kobe, Japan
H Kitaguchi

⁵The First Department of Physiology, Kobe University School of Medicine, Kobe, Japan
S Fucharoen

³The Thalassaemia Centre, Bangkok, Japan
S Sato

⁶The Department of Hygiene, Kobe University School of Medicine, Kobe, Japan
N Bhamarapravati

⁴The Vaccine Centre, Salaya, Mahidol University, Thailand

Abstract

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Summary

An increased level of plasma thrombomodulin (TM) in α- and β- thalassaemia was demonstrated using an enzyme-linked immunosorbent assay (ELISA). Nonsplenectomized patients with β-thalassaemia/ haemoglobin E (BE) had higher levels of TM than splenectomized cases (BE-S). Patients with leg ulcers (BE-LU) were found to have the highest increase in TM level. Appearance of larger platelets in all types of thalassaemic blood was observed indicating an increase in the number of younger platelets. These data indicate that injury of vascular endothelial cells is present in thalassaemic patients.

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References

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