Summary
Intra- and interindividual variation of phylloquinone (vitamin K1) concentrations was investigated by repeat analysis of serum from 28 hemodialysis
patients with different apolipoprotein E genotypes. Phylloquinone concentrations ranged
from 0.1 to 9.0 nM, with a mean of 1.08 nM (standard deviation 1.90 nM).
Most of the variation in serum phylloquinone concentrations was due to differences
between patients; the ratio of intra-to interindividual variation was 0.17. Serum
triglyceride concentrations and apoE genotype together accounted for 64% of interindividual
variation; in contrast, only 6% of intraindividual variation could be attributed to
differences in triglyceride concentrations.
The small residual variance implies that different phylloquinone consumption levels
contributed relatively little to the variation of serum concentrations (<36% of interindividual
variance). The results suggest that individual disposition is a more important determinant
of serum phylloquinone concentrations than dietary phylloquinone intake.
