Thromb Haemost 1995; 74(05): 1386-1387
DOI: 10.1055/s-0038-1649951
Letter To The Editor
Schattauer GmbH Stuttgart

β-Propiolactone UV Inactivated Clotting Factor Concentrate Is the Source of HIV-Infection of 8 Hemophilia B Patients: Confirmed

B Kupfer
1   The Institut für Medizinische Mikrobiologie und Immunologie, Germany
,
J Oldenburg
2   The Institut für Experimentelle Hamatologie und Transfusionsmedizin of the University of Bonn, Germany
,
H H Brackmann
2   The Institut für Experimentelle Hamatologie und Transfusionsmedizin of the University of Bonn, Germany
,
B Matz
1   The Institut für Medizinische Mikrobiologie und Immunologie, Germany
,
K E Schneweis
1   The Institut für Medizinische Mikrobiologie und Immunologie, Germany
,
R Kaiser
1   The Institut für Medizinische Mikrobiologie und Immunologie, Germany
› Author Affiliations
Further Information

Publication History

Received 08 May 1995

Accepted after resubmission 24 July 1995

Publication Date:
10 July 2018 (online)

 
  • References

  • 1 Kleim JP, Bailly E, Schneweis KE, Brackmann HH, Hammerstein U, Hanfland P, van Loo B, Oldenburg J. Acute HIV infection in patients with hemophilia B treated with β-propiolyctone-UV-inactivated clotting factor. Thromb Haemost 1990; 64: 336-337
  • 2 Kleim JP, Ackermann A, Brackmann HH, Gahr M, Schneweis KE. Epidemiologically closely related viruses from hemophilia B patients display high homology in two hypervariable regions of the HIV-1 env gene. AIDS Res Hum Retroviruses 1991; 7: 417-421
  • 3 Cichutek K, Norley S, Linde R, Kreuz W, Gahr M, Löwer J, von Wangenheim G, Kurth R. Lack of HIV-1 V3 region sequence diversity in two haemophiliac patients infected with a putative biologic clone of HIV-1. AIDS 1991; 5: 1185-1187
  • 4 Kasper P, Kaiser R, Kleim JP, Oldenburg J, Brackmann HH, Rockstroh J, Schneweis KE. Diversification of HIV-1 strains after infection from a unique source. AIDS Res Hum Retroviruses 1993; 9: 153-157
  • 5 Kasper P, Kaiser R, Oldenburg J, Brackmann HH, Matz B, Schneweis KE. Parallel evolution in the V3 region of HIV type 1 after infection of hemophiliacs from a homogeneous source. AIDS Res Hum Retroviruses 1994; 10: 1669-1678