Thromboxane Generation in Patients with Essential Hypertension or Cerebrovascular Disease and Effect of Oral Aspirin

Summary

The ability of platelets to synthesize thromboxane B₂ (TxB₂) from arachidonic acid (AA) or prostaglandin H₂ (PGH₂) was studied in 26 control subjects, 40 patients with essential hypertension, 20 patients with cerebrovascular disease (CVD) not taking aspirin and 11 patients with CVD taking aspirin. The activity of platelets to form TxB₂ from AA or PGH₂ was measured using 1 — ¹⁴C arachidonic acid or 1—¹⁴C PGH₂ as a substrate. There was no significant difference in TxB₂ generation from AA or PGH₂ among the platelets collected from the control subjects, hypertensive patients and CVD patients not taking aspirin.

In CVD patients taking aspirin, marked suppression was observed in TxB₂ synthesis from AA, but no suppression in TxB₂ synthesis from PGH₂. At least 750 mg aspirin per day were required for nearly complete suppression of TxB₂ generation from AA.

Key words

Thromboxane generation - Hypertension - Cerebrovascular disease - Aspirin - Prostaglandin - Platelet

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