Labelling of Blood Platelets with Stable Tracers

Summary

Half-time values of platelets labelled with stable rubidium are compared to those of platelets labelled with Cr⁵¹. Platelets labelled with stable rubidium are assayed by a very simple version of the X-Ray fluorescence equipment. The mean quantity of rubidium incorporated by the cells is of about some µg Rb per ml blood.

The in vitro half-time of human Rb labelled platelets stored at 22° C is 41.2 ± 3h compared with the value 44.8 ± 3h for platelets labelled with Cr⁵¹, as deduced by six experiments. The in vivo half-time of rabbit platelets labelled with stable rubidium is 22 ± 3h compared with the value 18 ± 3h of platelets labelled with Cr⁵¹; ten experiments were carried out.

Key words

Blood platelets - Survival; stable tracers

• References

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