Warfarin Induced Skin Necrosis Associated with Activated Protein C Resistance

• References

• 1 McGehee WG, Klotz TA, Epstein DJ, Rapaport SI. Coumarin necrosis associated with hereditary protein C deficiency. Ann Int Med 1984; 100: 59-60
• 2 Craig A, Taberner DA, Fisher AH, Foster DN, Mitra J. Type I protein S deficiency and skin necrosis. Postgraduate Med J 1990; 66: 389-391
• 3 Cole MS, Minifee PK, Wolma FJ. Coumarin necrosis-A review of the literature. Surgery 1988; 103: 271-277
• 4 Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study. Lancet 1993; 342: 1503-1506
• 5 Bertina MR, Koeleman BPC, Koster T, Rosendaal FR, Diwen RJ, De Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67