Fibrinogen and Factor Vllag in Healthy Adolescents: The Floren-teen (Florence Teenager) Study

Domenico Prisco; Sandra Fedi; Tamara Brunelli; Anna Paola Cellai; Mohamed Isse Hagi; Roberto Gianni; Emilio Santoro; Carlo Cappelletti; Guglielmina Pepe; Gian Franco Gensini; Rosanna Abbate

doi:10.1055/s-0038-1650366

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1996; 75(05): 778-781
DOI: 10.1055/s-0038-1650366

Original Article

Schattauer GmbH Stuttgart

Fibrinogen and Factor Vllag in Healthy Adolescents: The Floren-teen (Florence Teenager) Study

Authors

Domenico Prisco

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Sandra Fedi

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Tamara Brunelli

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Anna Paola Cellai

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Mohamed Isse Hagi

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Roberto Gianni

²Nuovo Ospedale San Giovanni di Dio, Florence, Italy
Emilio Santoro

²Nuovo Ospedale San Giovanni di Dio, Florence, Italy
Carlo Cappelletti

²Nuovo Ospedale San Giovanni di Dio, Florence, Italy
Guglielmina Pepe

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Gian Franco Gensini

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence
Rosanna Abbate

¹The Istituto di Clinica Medica Generale e Cardiologia University of Florence

Abstract

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Summary

At least five studies based on more than twenty thousand healthy subjects indicated that fibrinogen is an independent risk factor for cardiovascular events; less clear-cut is the relation between factor VII and risk for arterial thrombotic disorders, which was demonstrated in two of the three studies investigating this association. However, no study has investigated the behaviour of fibrinogen and factor VII in an adolescent population. In a study of Preventive Medicine and Education Program, fibrinogen (clotting method) and factor Vllag (ELISA), in addition to other metabolic parameters, life-style and familial history, were investigated in 451 students (313 females and 138 males, age 15-17 years) from two high schools of Florence. Fibrinogen levels were significantly higher in women than in men, whereas factor Vllag levels did not significantly differ. Both fibrinogen and factor Vllag significantly correlated with total cholesterol (p <0.05) while only fibrinogen correlated with body mass index (p <0.01). Factor Vllag was significantly correlated with systolic blood pressure (p <0.001). This study provides information on coagulation risk factors in a population of adolescents which may be of importance in planning coronary heart disease prevention programs.

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References

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