Enhanced Platelet Aggregability under High Shear Stress after Treadmill Exercise in Patients with Effort Angina

Junya Tokuue; Junichi Hayashi; Yoshiya Hata; Kazuhiko Nakahara; Yasuo Ikeda

doi:10.1055/s-0038-1650375

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1996; 75(05): 833-837
DOI: 10.1055/s-0038-1650375

Original Article

Schattauer GmbH Stuttgart

Enhanced Platelet Aggregability under High Shear Stress after Treadmill Exercise in Patients with Effort Angina

Authors

Junya Tokuue

¹The Department of Medicine and Gerontology, Tokyo, Japan
Junichi Hayashi

¹The Department of Medicine and Gerontology, Tokyo, Japan
Yoshiya Hata

¹The Department of Medicine and Gerontology, Tokyo, Japan
Kazuhiko Nakahara

²The Department of Clinical Pathology, Kyorin University, Tokyo, Japan
Yasuo Ikeda

³The Division of Hematology, Department of Medicine, Keio University, Tokyo, Japan

Abstract

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Summary

Platelet activation induced by shear forces occurring in a stenosed coronary artery is one of the mechanisms of coronary thrombosis. We evaluated the shear-induced platelet aggregation (SIPA) dynamics in patients with effort angina during treadmill exercise. SIPA was measured by a rotational cone-plate aggregometer. SIPA was markedly increased by exercise from 71.2 ± 8.9% to 81.9 ± 7.6% (p <0.01) in the patient group. Although epinephrine concentrations were elevated, its rate of increase was not correlated with that of SIPA. Yohimbine partially inhibited the exercise-induced increase in SIPA. In contrast, a significant correlation between the changing rate of plasma von Willebrand factor (vWF) larger multimers and that of SIPA (r = 0.74, p <0.05) was observed. Exercise-augmented SIPA is probably dependent on an increase in vWF larger multimers rather than platelet alpha₂-receptor activation. Prevention of the interaction between vWF and its platelet receptors may play some role in decreasing the risk of coronary thrombosis during exercise.

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References

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