Thromb Haemost 1996; 76(06): 1080-1085
DOI: 10.1055/s-0038-1650709
Original Article
Schattauer GmbH Stuttgart

Pathogenetic Analysis of Five Cases with a Platelet Disorder Characterized by the Absence of Thromboxane A2(TXA2)-Induced Platelet Aggregation in Spite of Normal TXA2 Binding Activity

Ichiro Fuse
1   The First Department of Internal Medicine, Niigata University School of Medicine, Niigata City, Japan
,
Akira Hattori
2   The Department of Internal Medicine, Sado Kouseiren Hospital, Japan
,
Masao Mito
3   The Department of Internal Medicine, Niigata Kobari Hospital, Japan
,
Wataru Higuchi
1   The First Department of Internal Medicine, Niigata University School of Medicine, Niigata City, Japan
,
Kazuaki Yahata
4   The Department of Internal Medicine, Nagaoka Central Hospital, Japan
,
Akira Shibata
1   The First Department of Internal Medicine, Niigata University School of Medicine, Niigata City, Japan
,
Yoshifusa Aizawa
1   The First Department of Internal Medicine, Niigata University School of Medicine, Niigata City, Japan
› Author Affiliations
Further Information

Publication History

Received 11 March 1996

Accepted after resubmission 23 August 1996

Publication Date:
11 July 2018 (online)

Summary

Five patients with mild bleeding tendencies characterized by defective thromboxane A2 (TXA2)-induced platelet aggregation are reported. The platelets of all the patients had the ability to bind exogenous TXA2. Bleeding time was markedly prolonged in one patient. In three of the five patients, synthetic TXA2 mimetic (STA2)-induced platelet responses, including IP3 formation, Ca2+ mobilization, phosphatidic acid formation and GTPase activities were selectively defective, suggesting impaired coupling between the TXA2 receptor and phospholipase C activation. However, in the remaining two patients, these responses were all within normal limits. This suggests that the defective site of this type of platelet disorder is heterogenous and that signaling mechanisms other than the TXA2 receptor-phospholipase C pathway are also involved in TXA2-induced platelet aggregation.

 
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