Summary
The intravenous injection of fibrinogen was associated with a prolonged hyperfibrinogenemia
in the rabbit, out of proportion to the amount of fibrinogen administered. Factors
V, II, VII and X activities were found to be elevated in the plasma simultaneously.
A similar pattern of changes was observed in the rabbit after the recovery period
from thrombin-induced defibrination.
Based on the observations reported here, it was suggested that some fibrinogen or
fibrin break-down products deliver the stimulatory message to the liver for increased
fibrinogen production.
The possible relationship between these observations and hypercoagulable state has
been discussed.
