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Thromb Haemost 1968; 19(03/04): 547-555
DOI: 10.1055/s-0038-1651234
Originalarbeiten – Original Articles – Travaux Originaux
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Studies on the Hypercoagulable State

The Regulation of Fibrinogen Production in Experimental Hyper- and Hypofibrinogenemia
M. L Kropatkin
1   Hematology Research Laboratory, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, Jerusalem, Israel
,
G Izak
1   Hematology Research Laboratory, Hadassah University Hospital and the Hebrew University-Hadassah Medical School, Jerusalem, Israel
› Author Affiliations
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Publication Date:
27 June 2018 (online)

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Summary

The intravenous injection of fibrinogen was associated with a prolonged hyperfibrinogenemia in the rabbit, out of proportion to the amount of fibrinogen administered. Factors V, II, VII and X activities were found to be elevated in the plasma simultaneously.

A similar pattern of changes was observed in the rabbit after the recovery period from thrombin-induced defibrination.

Based on the observations reported here, it was suggested that some fibrinogen or fibrin break-down products deliver the stimulatory message to the liver for increased fibrinogen production.

The possible relationship between these observations and hypercoagulable state has been discussed.

 

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