Decreased Myocardial Fibrinolytic Activity Following Temporary Ischaemia and Reperfusion

Summary

The effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and ^{12 5}I fibrinogen incorporation into fibrin was investigated in nine baboons.

Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the ^{12 5}I fibrinogen activity was elevated by 480%.

The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.

• References

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