Decreased Myocardial Fibrinolytic Activity Following Temporary Ischaemia and Reperfusion

George W Cherry; L. H Opie

doi:10.1055/s-0038-1651368

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1975; 34(01): 210-215
DOI: 10.1055/s-0038-1651368

Original Article

Schattauer GmbH

Decreased Myocardial Fibrinolytic Activity Following Temporary Ischaemia and Reperfusion

Authors

George W Cherry

¹Ischaemic Heart Disease Laboratory, Department of Medicine, University of Cape Town, South Africa
L. H Opie

¹Ischaemic Heart Disease Laboratory, Department of Medicine, University of Cape Town, South Africa

Abstract

Summary

The effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and ¹² ⁵I fibrinogen incorporation into fibrin was investigated in nine baboons.

Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the ¹² ⁵I fibrinogen activity was elevated by 480%.

The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.

Volltext

Referenzen

References
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