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Thromb Haemost 1975; 34(01): 210-215
DOI: 10.1055/s-0038-1651368
Original Article
Schattauer GmbH

Decreased Myocardial Fibrinolytic Activity Following Temporary Ischaemia and Reperfusion

George W Cherry
1   Ischaemic Heart Disease Laboratory, Department of Medicine, University of Cape Town, South Africa
,
L. H Opie
1   Ischaemic Heart Disease Laboratory, Department of Medicine, University of Cape Town, South Africa
› Author Affiliations
Further Information

Publication History

Received 09 January 1975

Accepted 11 March 1975

Publication Date:
02 July 2018 (online)

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Summary

The effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and 12 5I fibrinogen incorporation into fibrin was investigated in nine baboons.

Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the 12 5I fibrinogen activity was elevated by 480%.

The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.

 

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