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Thromb Haemost 1977; 38(02): 0504-0509
DOI: 10.1055/s-0038-1651856
Original Article
Schattauer GmbH

Heparinised Clotting Factor Concentrates in Patients with Christmas Disease and Liver Disease

F. E Preston
1   University Department of Haematology, The Royal Infirmary, Sheffield S6 3 DA, England
,
R. G Malia
1   University Department of Haematology, The Royal Infirmary, Sheffield S6 3 DA, England
,
J. S Lilleyman
1   University Department of Haematology, The Royal Infirmary, Sheffield S6 3 DA, England
,
E. K Blackburn
1   University Department of Haematology, The Royal Infirmary, Sheffield S6 3 DA, England
› Author Affiliations
Further Information

Publication History

Received 18 February 1977

Accepted 06 April 1977

Publication Date:
04 July 2018 (online)

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Summary

Evidence has been sought of activation of the coagulation system in two groups of patients following the infusion of two heparinised clotting factor concentrates. No changes were detected in 13 patients with mild hepatic dysfunction. In six studies on patients with Christmas disease induced abnormalities occurred in only one. Activation of the coagulation mechanism did not occur in another individual who had received the same batch of material.

 

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