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Thromb Haemost 1977; 38(03): 0652-0659
DOI: 10.1055/s-0038-1651880
Original Article
Schattauer GmbH

Megakaryocytes in the Giant Platelet Syndrome

A Cytochemical and Ultrastructural Study
Lawrence Kass
1   Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
,
David A. Leichtman
1   Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
,
Theodore F. Beals
1   Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
,
Bertram Schnitzer
1   Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 15 December 1976

Accepted 14 June 1977

Publication Date:
04 July 2018 (online)

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Summary

When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes also showed decreased glycogen and RNA (ribosomes) as well as aberrations of nuclear lobulation.

 

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