Heparin Neutralizing Activity (HNA) and Antithrombin III in Coronary Artery Disease

G Cella; R Russo

doi:10.1055/s-0038-1651885

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 38(03): 0696-0700
DOI: 10.1055/s-0038-1651885

Original Article

Schattauer GmbH

Heparin Neutralizing Activity (HNA) and Antithrombin III in Coronary Artery Disease

G Cella^*

¹Istituto di Semeiotica Medica, Cattedra di Fisiopat. Cardiocircolat., University of Padua Medical School, Padua, Italy

,

R Russo

¹Istituto di Semeiotica Medica, Cattedra di Fisiopat. Cardiocircolat., University of Padua Medical School, Padua, Italy

› Author Affiliations

Abstract

Summary

Plasma from 14 patients with severe and diffuse coronary atherosclerosis has been compared with that obtained from a normal control group. While a decreased he parin-thrombin clotting time was demonstrated in the patient group, suggesting an increased level of circulating platelet factor 4, there was no significant alteration in plasma antithrombin III level. These results do not support a recent suggestion of a mild chronic intravascular coagulation in atherosclerosis.

Full Text

References

References
1 Biggs R, Denson K. W. E, Akman N, Borrett R, Hadden M. 1970; Antithrombin III, antifactor Xa and heparin. British Journal of Haematology 19: 283.
2 Brunetti A, Shivazappa L, Cafiero F, Zucchetto M, Miraglia G, Stritoni P, Girolami A. 1974; Alcuni parametri coagulativi nei coronaropatici. Tentativo di definizione di uno stato ipecoagulabile. Bollettino della Società Italiana di Cardiologia 20: 517.
3 Conley L. G, Hartmann R. C, Lalley J. S. 1948; The relationship of heparin activity to platelet concentration. Proceedings of the Society for Experimental Biology and Medicine 69: 284.
4 Genton E, Weily H. S, Steele P. P. 1973; Platelets, thrombosis and coronary artery disease. Advances in Cardiology 9: 29.
5 Hardisty R. M, Ingram G. I. C. 1965. Bleeding Disorders. Blackwell Scientific Publications; Oxford.:
6 Hender U, Nilsson I. M. 1973; Antithrombin III in a clinical material. Thrombosis Research 3: 631.
7 Holger Madsen T. 1960; Heparin resistance in acute coronary occlusion, measured by the plasma heparin thrombin time. Acta Haematologica 23: 195.
8 Käser-Glanzmann R, Jakobova M, Lüscher E. F. 1972; Isolation and some properties of the heparin-neutralising factor (PF4) released from human blood platelets. Experientia 28: 1221.
9 Marciniak E, Florey C. H, De Simone P. A. 1974; Familial thrombosis due to antithrombin III deficiency. Blood 43: 219.
10 Nath N, Lowery G. T, Niewiarowski S. 1975; Antigenic and antiheparin properties of human platelet factor 4 (PF4). Blood 45: 537.
11 O’Brien J. R, Etherington M, Jamieson S, Klaber M. R, Lincoln S. V. 1974; Platelet function long after arterial and venous thrombosis. Thrombosis et Diathesis Haemorrhagica 31: 279.
12 O’Brien J. R. 1974; Anti-thrombin III and heparin clotting times in thrombosis and atherosclerosis. Thrombosis et Diathesis Haemorrhagica 32: 116.
13 O’Brien J. R, Etherington M, Jamieson S, Lawford P, Sussex J, Lincoln S. V. 1975; Heparin neutralizing activity test in the diagnosis of acute myocardial infarction. Journal of Clinical Pathology 28: 975.
14 Sagar S, Stamatakis J. D, Thomas D. P, Kakkar V. V. 1976; Oral contraceptives, antithrombin III activity and postoperative deep vein thrombosis. Lancet 1: 509.
15 Sagar S, Stamatakis J. D, Higgins A. F, Nairn D, Maffei F. H, Thomas D. P, Kakkar V. V. 1976; Efficacy of low-dose heparin in prevention of extensive deep-vein thrombosis in patients undergoing total hip replacement. Lancet 1: 1151.
16 Yin E. T, Wessler S, Stoll P. J. 1971; Biological properties of the naturally occurring plasma inhibitor to activated Factor X. Journal of Biological Chemistry 246: 3703.
17 Yin E. T, Wessler S, Butler J. V. 1973; Plasma heparin: A unique, practical submicrogram sensitive assay. Journal of Laboratory and Clinical Medicine 81: 289.