Modification Of The Haemostatic System By Atherogenic Diets In Rats

We have studied the haemostatic system and its modification due to different atherogenic diets in Sprague-Dawley rats. The diets administrated were an original previous ly described atherogenic model and its two constituent phases; a first phase of 3 days (hypervitaminic-D₂) that produced calcic infiltration followed by a second one of 12 days (hyperlipidic) that induced lipid deposition.

The hypervitaminic diet induced a highly significant (2p< 0.001) increase on triglycerides (TGL); the total-CHO/ HDL-CHO ratio decreased slightly. It induced a highly increase of the index of thrombodynamic potential (ITP) with out modification of fibrinolytic activity and fibrinolytic inhibitors.

The hyperlipidic diet induced a highly significant increase (2p<0.001) of TGL, CHO and VLDL. The total-CHO/ HDL-CHO ratio decreased markedly (2p <0.001). This diet by itself did not produced vascular morphological lesions. It was obtained a slight increase in the ITP, a significant de crease in fibrinolytic activity of whole blood without modT fication of diluted blood fibrinolytic activity and an increase in the level of fibrinolytic inhibitors.

The experimental model, arranged by the two phases consecutively given, induced a highly (2p<0.001) increase of CHO, TGL and VLDL. The total-CHO/HDL-CHO ratio decreased markedly (2p <0.001). The ITP was also increased; fibrinolytic activity of whole blood was diminished without modifica tion of diluted blood and fibrinolytic inhibitors were increased.

Thus, this experimental model induced an atheroscle- ritic pattern with activation of the coagulation system, due to the hypervitaminic phase, and decrease of fibrinolytic activity and increase of fibrinolytic inhibition, due to the hyperlipidic phase.