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Thromb Haemost 1981; 46(02): 525-527
DOI: 10.1055/s-0038-1653402
Original Article
Schattauer GmbH Stuttgart

Factor VIII : C and Factor VIII R: Ag in Argentine Hemorrhagic Fever

Felisa C Molinas
Sección Hematología, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Buenos Aires and Centro de Estudios sobre Fiebre hemorrágica argentina, Pergamino, Buenos Aires, Argentina
,
Julio I Maiztegui
Sección Hematología, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Buenos Aires and Centro de Estudios sobre Fiebre hemorrágica argentina, Pergamino, Buenos Aires, Argentina
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Publication History

Received 09 February 1981

Accepted 22 May 1981

Publication Date:
26 July 2018 (online)

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Summary

Factor VIII procoagulant activity (F VIII: C) and factor VIII related antigen (F VIII R: Ag) were investigated in 35 patients with Argentine hemorrhagic fever. Since the results obtained in the three clinical forms of the disease were not significantly different, they were tabulated altogether. F VIII: C was low in early stages of the disease but increased progressively in later days (days 5–6:0.54 ± 0.10 I.U./ml; days 13–14:0.95 ± 0.13 I.U./ml). In contrst, the levels of F VIII R: Ag were high all along the disease and they returned to normal values during the convalescence period (days 5–6; 2.58 ± 0.54 I.U./ml; day 30: 1.30 ± 0.14 I.U./ml). The levels of F VIII R: Ag were similar in samples drawn before (11 cases) or after (10 cases) the treatment with immune plasma infusion. Plasma samples from 12 patients were studied by two-dimensional immunelectrophoresis. The only abnormality found was increased height of the immune precipitation arc.

Keywords

F VIII: C–F VIIIR: Ag - Argentine hemorrhagic fever
 

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