Delayed Elimination of Fibrin from the Lungs in Rats Given α₂-Antiplasmin

Summary

Injection of human α₂–antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin–induced intravascular coagulation. The amount of α₂–antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiolabelled α₂–antiplasmin a specific uptake of this protein in the lungs was noted after the thrombin-induced coagulation. The results may indicate that the posttraumatic increase in α₂–antiplasmin is of significance for the delayed elimination of fibrin seen in patients following trauma.

Keywords

α₂–antiplasmin - Adult respiratory distress syndrome - Fibrinolysis in vivo

• References

• 1 Busch C, Dahlgren S, Jakobsson S, Jung B, Modig J, Saldeen T. The use of¹²⁵I-labelled fibrinogen for determination of fibrin trapping in the lungs in patients developing the microembolism syndrome. Acta Anaesthesiol Scand 1975; Suppl 57: 46-54
• 2 Saldeen T. The microembolism syndrome. Microvasc Res 1976; 11: 227-259
• 3 Saldeen T. The microembolism syndrome. In: The Microembolism Syndrome. Publ: Almqvist & Wiksell Int; Stockholm: 1979: 7-44
• 4 Collen D. On the regulation and control of fibrinolysis. Thromb Haemostas 1980; 43: 77-89
• 5 Bagge L, Saldeen T. The primary fibrinolysis inhibitor and trauma. Thromb Res 1978; 13: 1131-1136
• 6 Bagge L, Rammer L, Saldeen T. Experimental study of the importance of plasminogen activation inhibition for decreased elimination of intravascular fibrin after trauma. Forensic Sd 1973; 2: 54-55
• 7 Wiman B, Collen D. Purification and characterisation of human antiplasmin, the fast-acting plasmin inhibitor in plasma. Eur J Biochem 1977; 78: 19-26
• 8 Busch C, Rammer L, Saldeen T. Quantitation of fibrin deposition and elimination in organs of rats injected with labelled fibrinogen and albumin. Thrombos Diathes haemorrh 1973; 29: 94-107
• 9 Nilsson IM, Olow B. Determination of fibrinogen and fibrinogenolytic activity. Thrombos Diathes haemorrh 1962; 8: 297-310
• 10 Carlin G, Modig J, Saldeen T. Effect of infusion of dextran 70 on fibrinolysis inhibition activity in human serum. Acta Chir Scand 1979; 145: 129-131
• 11 Hogstorp H, Jacobsson H, Saldeen T. Effect of hepatectomy on the posttraumatic fibrinolysis inhibition and the primary fibrinolysis inhibitor in the rat. Thromb Res 1980; 18: 361-368
• 12 Koie K, Kamiya T, Ogata K, Takamatsu J. α₂-plasmin-inhibitor defidency (Miyasato disease). Lancet 23.12.1978; 1334-1336