A Simple Technique for the Experimental Production of Acute Platelet Deficiency

R.C Dutton; R.L Dedrick; B.S Bulli

doi:10.1055/s-0038-1653547

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1969; 21(02): 367-372
DOI: 10.1055/s-0038-1653547

Originalarbeiten - Original Articles - Travaux Originaux

Schattauer GmbH

A Simple Technique for the Experimental Production of Acute Platelet Deficiency

Authors

R.C Dutton^*

¹Laboratory of Technical Development, Biomedical Engineering and Instrumentation Branch, and Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland
R.L Dedrick

¹Laboratory of Technical Development, Biomedical Engineering and Instrumentation Branch, and Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland
B.S Bulli^**

¹Laboratory of Technical Development, Biomedical Engineering and Instrumentation Branch, and Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland

Abstract

Summary

This report describes a new simple technique for producing acute controlled thrombocytopenia by allowing platelets to adhere to activated carbon granules or glass beads during hemoperfusion of an experimental animal. The level of platelet deficiency produced may be regulated by terminating perfusion when the desired level is reached. Perfusion on consecutive days removes the newly released platelets and restores the thrombocytopenic state.

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References

References
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