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Thromb Haemost 1967; 17(01/02): 214-221
DOI: 10.1055/s-0038-1654096
Originalarbeiten - Original Articles - Travaux Originaux
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The Prothrombin Time in the Newborn: Effect of Contact Activation[*]

J. N Shanberge
1   Departments of Pathology, Evanston Hospital, Evanston, Ill., and Northwestern University Medical School, Chicago, Ill.
,
T Matsuoka
1   Departments of Pathology, Evanston Hospital, Evanston, Ill., and Northwestern University Medical School, Chicago, Ill.
› Author AffiliationsSupported by USPHS NIH Grant # HE-09122 and the Thomas J. Dee and George C. Moody Memorial Research Funds of Evanston Hospital.
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Publication Date:
26 June 2018 (online)

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Summary

The effect of foreign-surface contact on prothrombin conversion in adult plasma is compared to that of the newborn. The tests utilized in this comparison were the one-stage prothrombin time of Quick, the second stage of the thromboplastin generation test, and the prothrombin consumption test or the serum prothrombin time. In all of these there is much less acceleration produced by foreign-surface contact in the plasma of the newborn. Acceleration of the prothrombin conversion time is directly related to an increase in activity of factors VII and XL At no time could an increase in prothrombin activity be demonstrated. The decreased acceleration produced by foreign-surface contact in the plasma of the newborn is due primarily to a decreased level of factor VII as well as those factors necessary for its activation.

* Presented in part at the 10th Congress of the European Society of Hematology, Strasbourg, August 23-28, 1965.


 

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