Consumption of Hageman Factor Activity in the Generalized Shwartzman Reaction Induced by Liquoid

G Müller-Berghaus; H. G Lasch

doi:10.1055/s-0038-1654150

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1970; 23(02): 386-404
DOI: 10.1055/s-0038-1654150

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Consumption of Hageman Factor Activity in the Generalized Shwartzman Reaction Induced by Liquoid

Its Prevention by Inhibition of Hageman Factor Activation^[*]

G Müller-Berghaus

¹Department of Medicine, Justus-Liebig-Universität, Giessen, Germany

,

H. G Lasch

¹Department of Medicine, Justus-Liebig-Universität, Giessen, Germany

› Institutsangaben

Abstract

Summary

The role of Hageman factor in triggering intravascular coagulation has been studied in rabbits injected intravenously with Liquoid. Besides changes of coagulation parameters characteristic of consumption coagulopathy (e.g. decrease in platelet counts, fibrinogen levels, factor V activity), a pronounced drop in Hageman factor activity was observed after injection of Liquoid. Likewise, the partial thromboplastin time became prolonged.

The activation of Hageman factor in vivo could be prevented by intravenous infusion of lysozyme. Twenty min after starting the lysozyme infusion, the partial thromboplastin time became prolonged from a mean of 29 sec to 108 sec. Animals infused with lysozyme and injected with a lethal dose of Liquoid did not develop a consumption coagulopathy. In the same manner, none of 10 animals treated with lysozyme developed the generalized Shwartzman reaction, whereas in the control group 19 out of 20 animals showed fibrin thrombi in the glomerular capillaries.

From the present study it may be concluded that the intravascular coagulation process after intravenous injection of Liquoid is triggered by Hageman factor activation.

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Referenzen

References
1 Margaretten W, Zunker H. O, McKay D. G. Production of the generalized Shwartzman reaction in pregnant rats by intravenous infusion of thrombin. Lab. Invest 13: 552 1964;
2 Müller-Berghaus G. Pathophysiology of disseminated intravascular coagulation. 17th Annual Symposium on Blood, Detroit 1969. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl 30: 45 1969;
3 Lasch H. G, Rodriguez-Erdmann F, Krecke H.-J. Quantitative und qualitative Veränderungen der Thrombozyten beim Sanarelli-Shwartzman-Phänomen. Verh. dtsch. Ges. inn. Med 515: 992 1961;
4 McKay D. G. Disseminated Intravascular Coagulation. An Intermediary Mechanism of Disease. Hoeber; New York, Evanston, London: 1964
5 Des Brez B. M, Horowitz H. I, Hook E. W. Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro. J. exp. Med 114: 857 1961;
6 Lipiński B, Worowski K, Jeljaszewicz J, Niewiarowski S, Bejniak L. Participation of soluble fibrin monomer complexes and platelet factor 4 in the generalized Shwartzman reaction. Thrombos. Diathes. haemorrh. (Stuttg.) 20: 285 1968;
7 Rodríguez-Erdmann F. Studies on the pathogenesis of the generalized Shwartzman reaction. III. Trigger mechanism for the activation of the prothrombin molecule. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 471 1964;
8 Graeff H, Mitchell P. S, Beller F. K. Fibrinolytic enzyme system of the kidney related to renal function after infusion of endotoxin in rabbits. Lab. Invest 19: 169 1968;
9 Thomas L, Good R. A. Studies on the generalized Shwartzman reaction. I. General observations concerning the phenomenon. J. exp. Med 96: 605 1952;
10 Horn B. G, Collins R. D. Studies on the pathogenesis of the generalized Shwartzman reaction. The role of granulocytes. Lab. Invest 18: 101 1968;
11 Hawiger J, Collins R. D, Horn R. G. Precipitation of soluble fibrin monomer complexes by lysosomal protein fraction of polymorphonuclear leukocytes. Proc. Soc. exp. Biol. (N. Y.) 131: 349 1969;
12 Palmerio G, Ming S. G, Frank E, Fine J. The role of the sympathetic nervous system in the generalized Shwartzman reaction. J. exp. Med 115: 609 1962;
13 Heiffer M. H, Mundy R. L, Mehlman B. Effect of lethal doses of bacterial endotoxin (E. coli) on sympathetic neurohormones of the rabbit. Amer. J. Physiol 198: 1307 1960;
14 Rosenberg J. C, Lillehei R. C, Longerbeam J, Zimmermann B. Studies on hemorrhagic and endotoxin shock in relation to vasomotor changes and endogenous circulating epinephrine, norepinephrine and serotonin. Ann. Surg 154: 611 1961;
15 Midler-Berghaus G, McKay D. G. Prevention of the generalized Shwartzman reaction in pregnant rats by α-adrenergic blocking agents. Lab. Invest 17: 276 1967;
16 Beeson P. B. Effect of reticulo-endothelial blockade on immunity to the Shwartzman phenomenon. Proc. Soc. exp. Biol. (N. Y.) 64: 146 1947;
17 Good B. A, Thomas L. Studies on the generalized Shwartzman reaction. II. The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with thorotrast or trypan blue. J. exp. Med 96: 625 1952;
18 Lee L. Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction. J. exp. Med 115: 1065 1962;
19 Adams G. W. M. A p-dimethylaminobenzaldehy de-nitrite method for the histochemical demonstration of tryptophane and related compounds. J. clin. Path 10 (01) 56 1957;
20 Ratnoff O. D, Menzie G. A new method for the determination of fibrinogen in small samples of plasma. J. Lab. clin. Med 37: 316 1951;
21 Schultze H. E, Schwick G. Die klinische Bedeutung der differenzierten Bestimmung von Prothrombin und Aeceleratoren der Blutgerinnung (I). Medizinische 1953; 1354.
22 Procter R. R, Rapaport S. I. The partial thromboplastin time with kaolin. Amer. J. clin. Path 36: 212 1961;
23 Hartert PL. Die Thrombelastographie, eine Methode zur physikalischen Analyse des Blutgerinnungsvorganges. Z. ges. exp. Med 117: 189 1951;
24 Nossel H. L, Rubin E.L, Drillings M, Hsieh R. Inhibition of Hageman factor activation. J. clin. Invest 47: 1172 1968;
25 Rodríguez-Erdmann F, Krecke H.-J, Lasch H. G, Bohle A. Über die morphologischen und gerinnungsanalytischen Veränderungen nach Liquoid. Ein Beitrag zur Pathogenese des Sanarelli-Shwartzman-Phänomens. Z. ges. exp. Med 134: 109 1960;
26 Evensen S. A, Jeremie M, Hjort P. F. Intravascular coagulation with generalized Shwartzman reaction induced by a heparin-like anticoagulant (Liquoid). Thrombos. Diathes. haemorrh. (Stuttg.) 18: 24 1967;
27 Rodriguez-Erdmann F, Lasch H. G. Quantitative und qualitative Störungen der Thrombozyten nach Injektion hochmolekularer Polymerer. Thrombos. Diathes. haemorrh. (Stuttg.) 5: 518 1961;
28 Thomas L, Smith R. T, von Korff R. Studies on the generalized Shwartzman reaction. VII. The role of fibrinogen in the deposition of fibrinoid after combined injections of endotoxin and synthetic acidic polymer. J. exp. Med 102: 263 1955;
29 Evensen S. A, Jeremie M. Intravascular coagulation with generalized Shwartzman reaction induced by Liquoid: lack of protection by extreme thrombocytopenia. Thrombos. Diathes. haemorrh. (Stuttg.) 19: 556 1968;
30 Thomas L, Brunson J, Smith R. T. Studies on the generalized Shwartzman reaction. VI. Production of the reaction by the synergistic action of endotoxin with three synthetic acidic polymers (sodium polyanethol sulfonate, dextran sulfonate, and sodium polyvinyl alcohol sulfonate). J. exp. Med 102: 249 1955;
31 Zunz E, Mena-Ugalde C, Vesselovsky O. Contribution à l’étude de l’action du polyanéthol-sulfonate sodique ou liquoïde sur la coagulation sanguine. Sang 9: 1 1935;
32 Chorine V. Mode d’action du liquoïde (Polyanétholsulfonate de sodium) dans la coagulation du sang. C. R. Soc. Biol. (Paris) 135: 451 1941;
33 Muller-Berghaus G. Unpublished data.
34 McKay D. G, Muller-Berghaus G, Gruse V. Activation of Hageman factor by ellagic acid and the generalized Shwartzman reaction. Amer. J. Path 54: 393 1969;
35 Müller-Berghaus G, Goldfinger D, Margaretten W, McKay D. G. Platelet factor 3 and the generalized reaction. Thrombos. Diathes. haemorrh. (Stuttg.) 18: 726 1967;