Thromb Haemost 1970; 24(01/02): 286-301
DOI: 10.1055/s-0038-1654235
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Streaming Potential

An Analysis of the Test Technique and Its Application to the Study of Thrombosis on Implant Materials[*]
K.W Edmark M.D**
1   Cardiovascular Associates Laboratory Providence Hospital Seattle, Washington 98122
,
J Davis
1   Cardiovascular Associates Laboratory Providence Hospital Seattle, Washington 98122
,
H.L Milligan
1   Cardiovascular Associates Laboratory Providence Hospital Seattle, Washington 98122
› Author Affiliations
Further Information

Publication History

Publication Date:
28 June 2018 (online)

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Summary

Bioelectric charge transfer at the blood-wall interface may be a crucial factor affecting thrombosis on implant materials. The in-vitro streaming potential test technique offers a very sensitive, yet simple, means for observing this interfacial electrokinetic charge phenomena. Particular attention to test control variables is required, however, to obtain valid, comparative results. Due to the dynamic, changing nature of some surfaces on the molecular scale, reproducibility of results is subject to question and necessitates repeated runs to gain assurance of results.

It is demonstrated that this method of evaluation is an extremely sensitive tool in the study of blood-surface inter-actions. Changes in streaming potentials are dramatically revealed upon introduction of minute quantities of blood protein elements and drugs affecting blood coagulation. The techniques for applying this test method to the study of thrombosis are illustrated.

Streaming potential testing is a possible tool for realizing quality control in the preparation of anti-thrombogenic materials for cardiovascular implants. It may serve as a check, both on the formation of a proper surface and on the stability of this surface under physiological environment conditions.

* Supported by a grant from The John A. Hartford Foundation.


** Address requests for reprints to: K.W. Edmark, M.D., Director, Cardiovascular Associates Laboratory, Providence Hospital, 17th and E. Jefferson, Seattle, Washington 98122.