Download PDF
Thromb Haemost 1959; 03(01): 098-109
DOI: 10.1055/s-0038-1654374
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Some Aspects of Kinetics of the First Stages of Blood Thromboplastin Formation

U Fisch
1   Coagulation Laboratory (Prof. F. Koller) of the Department of Medicine (Prof. P. H. Rossier) University of Zurich, Switzerland
,
F Duckert
1   Coagulation Laboratory (Prof. F. Koller) of the Department of Medicine (Prof. P. H. Rossier) University of Zurich, Switzerland
› Author Affiliations
Further Information

Publication History

Publication Date:
08 June 2018 (online)

   Permissions and Reprints

Summary

The first stages of blood thromboplastin generation were investigated. Plasma Thromboplastin Antecedent, Prephase Accelerator, and Hageman factor are involved in the reactions taking place during the lag period. This phase is followed by the formation of intermediate product I. Studying the kinetics of this particular reaction it was possible to attribute to factors VIII and IX the rôle of substrates and to Stuart-Prower factor the rôle of an enzyme. It appears that in haemophilia B serum two distinct factors are lacking, the genuine factor IX, and the prephase accelerator (PPA). An hypothesis explaining tentatively the activation of a precursor to PPA and genuine factor IX is offered.

 

  • References

  • 1 Bachmann F, Duckert F, Koller F. The Stuart-Prower factor assay and its Clinical Signification. Thromb. Diath. haem 1958; 2: 24
    PubMedGoogle Scholar
  • 2 Bergsagel D. E, Biggs R. The Christmas Factor. Rev. hémat 1955; 10: 354
    PubMedGoogle Scholar
  • 3 Bergsagel D. E, Hougie C. Intermediate Stages in the Formation of Blood Thromboplastin. Brit. J. Haemat 1956; 2: 113
    CrossrefPubMedGoogle Scholar
  • 4 Biggs R, Douglas A. S. The Thromboplastin Generation Test. J. clin. Pathol 1953; 6: 23
    CrossrefPubMedGoogle Scholar
  • 5 Duckert F, Flückiger P, Isenschmid H, Matter M, VogelMeng J, Koller F. A Modification of the Thromboplastin Generation Test. Acta haemat 1954; 12: 197
    CrossrefPubMedGoogle Scholar
  • 6 Fisch U. Über einen neuen Accelerator der Blutthrombokinasebildung. Thromb. Diath. haem 1958; 2: 60
    PubMedGoogle Scholar
  • 7 Geiger M, Duckert F, Koller F. (1956)Quantitative Bestimmungen von F. VIII und F. IX bei Blutersippen. Kongr. Europ. Ges. Haemat. 1955. Verlag Heidelberg; Springer:
    Google Scholar
  • 8 Hougie C. The Role of Factor V in the Formation of Blood Thromboplastin. J. Lab. clin. Med 1957; 50: 61
    PubMedGoogle Scholar
  • 9 Koller F, Loeliger A, Duckert F. Experiments on a new Clotting Factor (Factor VII). Acta haemat 1951; 6: 1
    CrossrefPubMedGoogle Scholar
  • 10 Ratnoff O. D, Colopy J. E. A Familiar Hemorrhagic Trait Associated with a Deficiency of a Clot-promoting Fraction of Plasma. J. clin. Invest 1955; 34: 602
    CrossrefPubMedGoogle Scholar
  • 11 Rosenthal R, Dreskin O. H, Rosenthal N. New Hemophilia like Disease Caused by Deficiency of a Third Plasma Thromboplastin Factor. Proc. Soc. exptl. Biol. Med 1953; 82: 171
    CrossrefPubMedGoogle Scholar