Some Properties of a Reaction Mechanism Analogous to Thrombin Formation

Summary

Using an analog computor, the behavior with respect to time of a model chemical reaction mechanism has been studied. This mechanism consists of a consecutive series of reactions, the product of which corresponds to a prothrombin activator that acts enzymatically upon prothrombin. The striking resemblance in behavior between the model mechanism and the natural system strengthens current concepts of prothrombin activator formation.

• References

• 1 Astrup T. The autocatalytic reaction in blood coagulation. Danish med. Bull 1957; 4: 160
• 2 Bergsagel D. E. The Role of Calcium in the Activation of the Christmas Factor. Brit. J. Hemat 1955; 1: 199
• 3 Bergsagel D. E, Hougie C. Intermediate stages in the formation of blood thromboplastin. Brit. J. Haematol 1956; 2: 113
• 4 Biggs R, Douglas A. S, Macfarlane R. G. The initial stages of coagulation. J. Physiol. (Lond.) 1953; 122: 538
• 5 Douglas A. S. Factor V consumption during blood coagulation. Brit. J. Haematol 2: 153 1956;
• 6 Macfarlane R. G. Blood coagulation. Physiol. Rev 1956; 36: 479
• 7 Seegers W. H, Johnson S. A. Conversion of prothrombin to autoprothrom-bin II (Platelet Cofactor II) and its relation to the blood clotting mechanism. Amer. J. Physiol 1956; 184: 259
• 8 Shinowara G. Y. The isolation and characterization of thromboplastic cell and plasma components. J. Lab. clin. Med 1951; 38: 11
• 9 Soroka: Analog methods in computation and simulation. McGraw Hill; New York: 1954
• 10 Surgenor D. M, Steele B. B. Platelet antihemophilic factor interactions. Fed. Proc 1958; 17: 1262
• 11 Surgenor D. M, Steele B. B, Wallach D. F. H. Thrombin formation in purified systems. Thrombosis et Diathesis Haemorrhagica 1959; 3: 214