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Thromb Haemost 1959; 3(04): 588-592
DOI: 10.1055/s-0038-1654414
Originalarbeiten — Original Articles — Travaux Originaux
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Prothrombin Utilization Following Addition of Platelet Cofactor I Concentrates to Hemophilic Plasma

J Frederic Johnson
1   Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA.
,
Eberhard F. Mammen
1   Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA.
,
Walter H. Seegers   *)
1   Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA.
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Publication History

Publication Date:
12 June 2018 (online)

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Summary

Prothrombin is utilized in hemophilia B blood when a platelet cofactor I concentrate is added. It is not well utilized when the same preparation is added to hemophilia B plasma, hemophilia A plasma, or hemophilia A blood. Platelet factor 3 concentrates did not promote prothrombin utilization. Mixtures of platelet cofactor I and platelet factor 3 (threone) give prothrombin utilization under all conditions tested in hemophilia A and B.

*) This investigation was supported by a research grant H-2026 from the National Heart Institute, National Institutes of Health. Funds for Research Fellowships in Physiology were provided by Parke, Davis and Company.


 

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