Thromb Haemost 1960; 4(02): 196-200
DOI: 10.1055/s-0038-1654496
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis[*]

Autoren

  • E. A Loeliger

    1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
  • B. v. d Esch

    1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
  • C. Ch ter Haar Romeny-Wachter

    1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
  • H. L Booij

    1   Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
17. Juni 2018 (online)

Summary

The range of the hourly turnover rate of factor VII, found in 17 normal individuals, 14 patients with thrombo-embolic diseases and 3 patients with congential hypoproconvertinaemia, was 11.1—16.6% of the total body pool of factor VII (mean normal value 13.8%). The possible significance of this rapid turnover rate of factor VII in prophylactic anticoagulant treatment with 4-hydroxycoumarin derivatives is stressed.

* This investigation was supported by the Netherlands Organization for Applied Scientific Research (T.N.O.).