Thromboplastic Activity of Split Products of Phosphatidyl Ethanolamine

Karl H. Slotta; Erwin Deutsch

doi:10.1055/s-0038-1654507

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1960; 4(02): 283-288
DOI: 10.1055/s-0038-1654507

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Thromboplastic Activity of Split Products of Phosphatidyl Ethanolamine

Authors

Karl H. Slotta

¹Departments of Biochemistry and Medicine, University of Miami School of Medicine, Coral Gablesy, Florida, and I. Medizin. Universitätsklinik Wien, Austria
Erwin Deutsch

¹Departments of Biochemistry and Medicine, University of Miami School of Medicine, Coral Gablesy, Florida, and I. Medizin. Universitätsklinik Wien, Austria

Abstract

Summary

Pure synthetic L-α-(dioleoyl) PE is inactive as a platelet substitute in the thromboplastin generation test, even when in a stable suspension. Under humid conditions it is partly hydrolyzed. Among the split products lyso PE and phosphoryl ethanolamine were identified. The resulting mixture has thromboplastin generating activity. This thromboplastin is formed slowly, but it is stable over longer periods of time than thromboplastins formed from PS + PC or PS + PE mixtures, which are rapidly generated and lose activity faster.

Full Text

References

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