Activation of Fibrinolysis in Guinea-Pig Serum by Bile Acids

Summary

Various bile acids produced fibrinolytic activity in guinea-pig serum under similar conditions as previously established for various anionic polyelectrolytes [Olesen (1959 b,c)].

“Tauroglycocholate“ furthermore produced fibrinolytic activity by simple addition to guinea-pig serum.

These reactions probably depend on polyanion interactions with active and/or inhibitory components of the fibrinolytic system.

The observations suggest that bile acids could be involved in producing fibrinolytic activity in the biliary system.

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