Download PDF
Thromb Haemost 1964; 11(01): 027-037
DOI: 10.1055/s-0038-1654803
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Increased Activity of “Anti-Willebrand Factor” in Diabetic Plasma

A. E Ödegaard
1   Institute for Thrombosis Research, University Hospital, Rikshospitalet, Oslo, Norway. Head: Prof. P. A. Owren, M. D
,
B. A Skalhegg
1   Institute for Thrombosis Research, University Hospital, Rikshospitalet, Oslo, Norway. Head: Prof. P. A. Owren, M. D
,
A. J Hellem
1   Institute for Thrombosis Research, University Hospital, Rikshospitalet, Oslo, Norway. Head: Prof. P. A. Owren, M. D
› Author AffiliationsSupported by grants from The Norwegian Council on Cardio-vascular Diseases.
Further Information

Publication History

Publication Date:
22 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

In a group of 25 patients with insulin-treated diabetes mellitus a marked increase in the ADP-induced platelet adhesiveness was demonstrated. This phenomenon was due to a plasmatic factor. In vitro-plasma from these patients restored the decreased ADP-induced platelet adhesiveness in von Willebrand’s disease.

The factor was also effective in vivo, since transfusion of 450 ml diabetic plasma to a patient with von Willebrand’s disease normalized the decreased platelet adhesiveness and shortened the prolonged bleeding time. The role of this factor in the ADP platelet reaction as a cofactor together with calcium is stressed.

 

  • References

  • 1 Born GVR. Aggregation of blood platelets by adenosine disphosphate and its reversals. Nature 194: 927 1962;
    PubMedSearch in Google Scholar
  • 2 Egeberg O. The effect of muscular exercise on hemostasis in von Willebrand’s disease. Scand. J. clin. Lab. Invest 15: 273 1963a
    PubMed
  • 3 Egeberg O. Changes in the activity of antihemophilic A factor (f. VIII) and in the bleeding time associated with muscular exercise. Scand. J. clin. Lab. Invest 05: 539 1963;
    PubMedSearch in Google Scholar
  • 4 Gaarder A. M, Jonsen J, Laland S, Hellem A, Owren P. A. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature 192: 531 1961;
    CrossrefPubMedSearch in Google Scholar
  • 5 Hellem A. J. The adhesiveness of human blood platelets in vitro. Thesis. Scand. J. clin. Lab. Invest 12 Suppl. 51 1960;
    PubMedSearch in Google Scholar
  • 6 Hellem A. J, Ödegaard A. E, Skalhegg B. A. Investigations on adenosine diphosphate (ADP) induced platelet adhesiveness in vitro. Part I. The ADP-platelet reaction in various conditions. Thrombos. Diathes. haemorrh. (Stuttg) 10: 61 1963;
    PubMedSearch in Google Scholar
  • 7 Hovig T. Release of platelet aggregating substance (adenosine diphosphate) from rabbit blood platelets induced by saline extracts of tendons. Thrombos. Diathes. haemorrh. (Stuttg) 09: 264 1963;
    PubMedSearch in Google Scholar
  • 8 Nilsson I. M, Blombäck M, Jorpes E, Blombäck B, Johansson S. A. von Willebrand’s disease and its correction with human plasma fraction 1—0. Acta med. scand. 159: 179 1957;
    PubMedSearch in Google Scholar
  • 9 Nygaard K. K. Aderect method of counting platelets in oxalated plasma. Proc. Mayo Clin. 08: 365 1963;
    PubMedSearch in Google Scholar
  • 10 Ödegaard A. E, Skalhegg B. A, Hellem A. J. ADP-induced platelet adhesiveness as a diagnostic test in von Willebrand’s disease. Thrombos. Diathes. haemorrh. (Stuttg) 11: 23 1964;
    PubMedSearch in Google Scholar
  • 11 Salzmann E. W. Measurement of platelet adhesiveness. J. lab. clin. Med. 62: 724 1963;
    PubMedSearch in Google Scholar
  • 12 Vainer H, Caen J. Utilisation d’un test photométrique pour l’étude de l’effet de l’ADP sur les plaquettes sanguines. Nouv. Rev. franç. Hémat. 03: 149 1963;
    PubMedSearch in Google Scholar
  • 13 Zucker M. B. In vitro abnormality of the blood in von Willebrand’s disease correctable by normal plasma. Nature 197: 601 1963;
    CrossrefPubMedSearch in Google Scholar
  • 14 Zucker M. B, Borelli J. Platelet clumping produced by connective tissue suspension and by collagen. Proc. Soc. exp. Biol. (N. Y) 109: 779 1962;
    CrossrefPubMedSearch in Google Scholar