Lysis of the Experimental Radioactive Pulmonary Embolus Induced by Streptokinase and SK-Activated Plasmin*

Michael Hume

doi:10.1055/s-0038-1654810

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1964; 11(01): 099-107
DOI: 10.1055/s-0038-1654810

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Lysis of the Experimental Radioactive Pulmonary Embolus Induced by Streptokinase and SK-Activated Plasmin^*

Michael Hume^**)

¹Department of Surgery, Yale University School of Medicine, New Haven, Connecticut

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Abstract

Summary

The experimental radioactive pulmonary embolus, made from human blood, introduced into the dog, was used to demonstrate efficacy of several streptokinase and SK-activated plasmin preparations. Demonstrable lysis was observed with each of these agents, but varied with dose administered, and with other factors still obscure. This experimental method presents several advantages for in vivo evaluation and comparison of thrombolytic agents, including the following: (1) The animal is large enough to permit multiple blood samples to be taken; (2) The test material is human and may be modified if desired; (3) Continuous observation is possible ; (4) Spontaneous lysis is differentiated from induced lysis by waiting during a control period for a steady state to be reached; (5) Several criteria of successful lysis confirm each other; (6) Residual embolus can be located at necropsy; (7) More than one dose or one agent can be given in a single experiment.

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Referenzen

References
1 Johnson A. J, McCarty W. R. The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J. clin. Invest. 38: 1627-1643 1959;
2 Hume M, Glenn WWL, Grillo T. Behavior in the circulation of the radioactive pulmonary embolus and its application to the study of fibrinolytic enzymes. Ann. Surg. 151: 507 1960;
3 Sawyer W. D, Alkjaersig N, Fletcher A. P, Sherry S. Studies on the thrombolytic activity of human plasma. J. Clin. Invest. 39: 426 1960;
4 Hume M. Radioactive (I¹³¹) human plasma clots for assay of thrombolytic activity. J. Lab. clin. Med. April, 1964 (inpress); Circulat. Res. 14: 1 1964;