The Circulating Anticoagulant in Disseminated Lupus Erythematosus

Herbert A. Perkins; D. J Acra

doi:10.1055/s-0038-1654922

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1961; 05(02): 250-255
DOI: 10.1055/s-0038-1654922

Originalarbeiten – Original Article – Travaux Originaux

Schattauer GmbH

The Circulating Anticoagulant in Disseminated Lupus Erythematosus

Herbert A. Perkins M. D.^*

¹Hematology Research Laboratory, the Jewish Hospital of St. Louis and the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri

,

D. J Acra^**

¹Hematology Research Laboratory, the Jewish Hospital of St. Louis and the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri

› Author Affiliations

Abstract

Summary

The circulating anticoagulant in a case of lupus erythematosus was demonstrated to accelerate the disappearance of formed thromboplastin. We were unable to show that it acted against any single blood coagulation factor. We suggest that its action may be entirely explained on the basis of destruction of the final prothrombin converting factor, with and without the presence of tissue thromboplastin. This hypothesis still leaves no explanation for the consistently low levels of prothrombin in this condition.

Full Text

References

References
1 Frick P. G. Acquired Circulating Anticoagulants in Systemic “Collagen Disease”, Autoimmune Thromboplastin Deficiency. Blood 10: 691 1955;
2 Biggs Rosemary, Macfarlane R. G. Human Blood Coagulation and its Disorders. 2. Ed. Blackwell Scientific Publications; Oxford: 1957
3 Rapaport S. I, Ames SaraBeth, Duvall BarbaraJ. A. Plasma Coagulation Defect in Systemic Lupus Erythematosus Arising from Hypoprothrombinemia Combined with Antiprothrombinase Activity. Blood 15: 212 1960;
4 Loeliger A. Prothrombin as Co-Factor of the Circulating Anticoagulant in Systemic Lupus Erythematosis. Thromb. Diath. haem. 03: 237 1959;
5 Owren P. A. A Quantitative One-Stage Method for the Assay of Prothrombin. Scand. J. Clin. Lab. Invest 01: 81 1949;
6 De Vries A, Alexander B, Goldstein R. A Factor in Serum which Accelerates the Conversion of Prothrombin to Thrombin. I. Its Determination and Some Physiologic and Biochemical Properties. Blood 04: 247 1949;
7 Stefanini M. New One-Stage Procedures for the Quantitative Determination of Prothrotnbin and Labile Factor. Amer. J. clin. Path. 20: 233 1950;