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Thromb Haemost 1962; 07(01): 027-034
DOI: 10.1055/s-0038-1655453
Originalarbeiten — Original Articles — Travaux Originaux
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Formation of an Inhibitor against Factor VIII as a Postoperative Complication in a Severe Case of Hemophilia A

E Beck
1   Coagulation Laboratory (Prof. F. Koller), Department of Medicine (Prof. P. H. Rossier), Kantonsspital, University of Zurich, Switzerland
,
F Bachmann
1   Coagulation Laboratory (Prof. F. Koller), Department of Medicine (Prof. P. H. Rossier), Kantonsspital, University of Zurich, Switzerland
,
J Müller
1   Coagulation Laboratory (Prof. F. Koller), Department of Medicine (Prof. P. H. Rossier), Kantonsspital, University of Zurich, Switzerland
,
F Duckert
1   Coagulation Laboratory (Prof. F. Koller), Department of Medicine (Prof. P. H. Rossier), Kantonsspital, University of Zurich, Switzerland
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Publication History

Publication Date:
21 June 2018 (online)

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Summary

A case of haemophilia A with formation of an inhibitor after transfusions as a postoperative complication is described. The inhibitor was active against factor VIII from human, bovine and porcine source. It corresponds to the progressively active type of inhibitor.

The necessity of a complete examination including incubation tests before operations and before the use of concentrated AHG on hemophiliacs is stressed. In the presence of an inhibitor of this type animal AHG should not be infused, because it will be inactivated as well as human AHG and provokes an additive species specific sensibilization.

 

  • References

  • 1 Bachmann F, Beck E, Akovbiantz A, Duckert F. Richtlinien für die Operation bei schwerer Hämophilie. Dtsch. med. Wschr. (in press)
    PubMedGoogle Scholar
  • 2 Bid well E. The purification of bovine antihaemophilic globulin. Brit. J. Haemat 1955; 1: 35
    CrossrefPubMedGoogle Scholar
  • 3 Biggs R, Bidwell E, Macfarlane R. G. The mode of action and aetiology of antihaemophilic globulin inhibitors. Sang 1959; 30: 340
    PubMedGoogle Scholar
  • 4 Biggs R, Macfarlane R. G. Hiuman Blood Coagulation and its Disorders. Blackwell; Oxford: 1957: 302-316.
    Google Scholar
  • 5 Dausset J. Les anticoagulants circulants sont-ils des anticorps?. Sang 1959; 30 (04) 428
    PubMedGoogle Scholar
  • 6 den G. J. HOttolander, Bleyenberg A. Personal communication
    PubMed
  • 7 Duckert F. Le diagnostic des coagulopathies. RÖntg. u. Lab.-Prax 1960; 13 (156) 171 203, 224
    PubMedGoogle Scholar
  • 8 Masure R. Les inhibiteurs normaux et pathologiques de la coagulation sanguine. Arscia/Masson; Bruxelles/Paris: 1960: 147-171.
    Google Scholar