Die Rolle der Kalziumionen bei der Regulation der Thrombozytenfunktion

R. E. Scharf; H.-J. Reimers; W. Schneider

doi:10.1055/s-0038-1656598

Hämostaseologie, Table of Contents

Hamostaseologie 1981; 01(03): 106-122
DOI: 10.1055/s-0038-1656598

Originalarbeiten

Schattauer GmbH

Die Rolle der Kalziumionen bei der Regulation der Thrombozytenfunktion^[*]

Authors

R. E. Scharf

¹Medizinischen Klinik und Poliklinik Klinik A (Direktor: Prof. Dr. W. Schneider) der Universität Düsseldorf
H.-J. Reimers

¹Medizinischen Klinik und Poliklinik Klinik A (Direktor: Prof. Dr. W. Schneider) der Universität Düsseldorf
W. Schneider

¹Medizinischen Klinik und Poliklinik Klinik A (Direktor: Prof. Dr. W. Schneider) der Universität Düsseldorf

Abstract

Full Text

References

LITERATUR
1 Baumgartner H. R, Muggli R. Adhesion and aggregation: morphological demonstration and quantitation in vivo and in vitro. In Gordon J. L. (ed) »Platelets in biology and pathology« North-Holland Publ. Comp. Amsterdam; New York, Oxford: 1976
2 Benveniste J, Henson P. M, Cochrane C. G. Leukocyte-dependent histamine release from rabbit platelets. The role of IgE basophils and a platelet activating factor. J. exp. Med 1972; 136: 1356
3 Benveniste J, Le Couedic J. P, Polons-ky J, Tence M. Structural analysis of purified platelet activating factor by lipases. Nature (Lond.) 1977; 269: 170
4 Bettex-Galland M, Lüscher E. F. Extraction of an actomyosin-like protein from human thrombocytes. Nature 1959; 184: 276
5 Bills T. K, Smith J. B, Silver M. J. Metabolism of ¹⁴C-arachinidonic acid by human platelets. Biochim. biophys. Acta 1976; 424: 303
6 Bills T. K, Smith J. B, Silver M. J. Intracellular regulation of the metabolism of arachidonic acid in human platelets. Thrombos. Haemostas 1978; 40: 219
7 Bishop G. A, Rozenberg M. C. The effect of ADP calcium and some inhibitors of platelet aggregation on protein phosphokinases from human blood platelets. Biochim. biophys. Acta 1975; 384: 112
8 Borisy G. G, Olmstead J. B, Marcum J. M, Allen C. Microtubule assembly in vitro. Fed. Proc 1974; 33: 167
9 Born G. V. R. Observations on the change of shape of blood platelets brought about adenosine diphosphate. J. Physiol. (Lond.) 1970; 209: 487
10 Brodie G. N, Baenziger N. L, Chase L. R, Majerus P. W. The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. J. clin. Invest 1972; 51: 81
11 Bouvier C. A, Gabbiani G, Majno G. Binding of anti-actin auto-antibodies to platelets. Vth International Congress on Thrombosis and Haemostasis. Abstr; Paris: 1975: 264
12 Bygrave F. L. Mitochondrial calcium transport. In Sanadi D. R. (ed.) »Current topics in bioenergetics«. Academic Press; London: 1977
13 Bygrave F. L. Calcium movements in cells. Trends Biochem. Sci 1978; 3: 175
14 Bygrave F. L. Mitochondria and the control of intracellular calcium. Biol. Rev 1978; 53: 43
15 Carafoli E. The interaction of Ca²⁺with mitochondria with special reference to the structural role of Ca ²⁺in mitochondrial and other membranes. Mol. Cell. Bio-chem 1975; 8: 133
16 Carafoli E, Malmström K, Capano M, Sigel E, Crompton M. Mitochondria and the regulation of cell calcium. In Carafoli E, Clementi F, Drabikowski W, Margret A. (eds.) »Calcium trnasport in contraction and secretion«. North-Holland Publ. Comp; Amsterdam: 1975
17 Carafoli E, Crompton M. The regulation of intracellular calcium. In Bronner F, Kleinzeller A. (eds.) »Current topics in membranes and transport, Vol. 10. Membrane properties: Mechanical aspects, receptors, energetics and calciumdepen-dence of transport«. Academic Press; New York: 1978
18 Cazenave J. P, Benveniste J, Mustard J. F. Aggregation of rabbit platelets by platelet activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs. Lab. Invest 1980; 41: 275
19 Charo I. F, Feinman R. D, Detwi-ler T. C. Inhibition of platelet secretion by an antagonist of intracellular calcium. Biochem. biophys. Res. Commun 1976; 72: 1462
20 Cheung W. Y. Cyclic 3’5’ nucleotide phosphodiesterase. Evidence for and properties of a protein activator. J. Biol. Chem 1971; 246: 2859
21 Cheung W. Y. Calmodulin plays a pivotal role in cellular regulation. Science 1980; 207: 19
22 Chignard M, Couedic J. P, Tence M, Vargaftig B. B, Benveniste J. The role of platelet activating factor in platelet aggre gation. Nature (Lond.) 1979; 279: 799
23 Cohen I, Cohen C. A tropomyosin-like protein from human platelets. J. molec. Biol 1972; 68: 383
24 Cohen I, de Vries A. Platelet contractile regulation in an isometric system. Nature 1973; 246: 36
25 Cohen J, Lüscher E. F. (eds.) The blood platelet contractile system. Haemostasis 1975; 4: 125
26 Cooper H. A, Mason R. G, Brinkhous K. M. The platelet membrane and surface reactions. Ann. Rev. Physiol 1976; 38: 501
27 Crawford N. Platelet microfilaments and microtubules. In Gordon J. L. (ed.) »Platelets in biology and pathology«. North-Holland Publ. Comp., Amsterdam; New York, Oxford: 1976
28 Crawford N, Taylor D. G. Biochemical aspects of platelet behaviour associated with surface membrane reactivity. In Thomas D. (ed.) »Haemostasis«. Brit. Med.; Bull: 33 1977: 199
29 Crawford N, Amos L. A, Castle A. G. Platelet microtubule submit proteins: assembly and disassembly factors. In Rot-man A, Meyer F. A, Gitler C, Silberberg A. (eds.) »Platelets: Cellular response mechanism and theit biological significance«. John Wiley and Sons Ltd; Chichester, New York, Brisbane, Toronto: 1980
30 Demopoulos C. A, Pinkard R. M, Hanahan D. J. Platelet activating factor. Evidence for l-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (A new class of lipid chemical mediators). J. biol. Chem 1979; 254: 9355
31 Detwiler T. C, Charo I. F, Fein-man R. D. Evidence that calcium regulates platelet function. Thromb. Haemostas 1978; 40: 207
32 Doery J. C. G, Hirsh J, de Gruchy G. C. Platelet metabolism and function. Haema-tologia 1970; 4: 405
33 Falcäo L. La démarcation des plaquettes sanguines dans les mégacaryocytes de la moelle osseuse humaine. Coagulation 1968; 1: 229
34 Feinman R. D, Detwiler T. C. Platelet secretion induced by divalent cation iono-phores. Nature 1974; 249: 172
35 Feinman R. D, Detwiler T. C. Abscence of a reguirement for extracellular calcium for secretion from platelets. Thromb. Res 1975; 7: 677
36 Feinstein M. B, Fiekers J, Fraser C. An analysis of the mechanism of local anaesthetic inhibition of platelet aggregation and secretion. J. Pharmacol. exp. Ther 1976; 197: 215
37 Feinstein M. B. Platelet calcium: factors affecting its distribution mobilization and action. Vllth International Congress on Thrombosis and Haemostasis, London, 1979, Abstr. 1037, Thromb. Haemostas 1979; 42: 432
38 Gerrard J. M, White J. G, Rao G. H. R, Townsend D. Localization of platelet prostaglandin production in the platelet dense tubular system. Amer. J. Path 1976; 83: 283
39 Gerrard J. M, Peterson D. A, Town-send A, White J. G. Prostaglandins and platelet contraction. Circulation Supp 1976; II: 196
40 Gerrard J. M, Townsend D, Stoddard S, Witkop Jr. C. J, White J. G. The influence of prostaglandin G₂on platelet ultra-structure and platelet secretion. Amer. J. Path 1977; 86: 99
41 Gerrard J. M, White J. G, Peterson D. A. The platelet dense tubular system: its relationship to prostaglandin synthesis and calcium flux. Thromb. Haemostas 1978; 40: 224
42 Gerrard J. M, White J. G, Peterson D. A. The platelet dense tubular system: its relationship to prostaglandin synthesis and calcium flux. Thromb. Haemostas 1978; 40: 224
43 Gitler C, Pribluda V, Laub F, Rot-man A. Platelet activation and the cytoskele-ton networks. In Rotman A, Meyer F. A, Gitler C, Silberberg A. (eds.) »Plate-lets: Cellular response mechanism and their biological significance«. John Wiley and Sons Ltd; Chichester, New York, Brisbane, Toronto: 1980
44 Glass D. B, White J. G, Goldberg N. D. Rapid elevation in cyclic GMP with epine-phrine-induced platelet aggregation. Fed. Proc 1974; 33: 611
45 Goldberg N. D, Haddox N. K, Nicol S. E, Glass D. M, Sandford C. H, Kuehl F. A, Estensen R. Biological regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin-Yang hypothesis. Adv. Cyclic Nucleotide Res 1974; 5: 307
46 Grette K. Relaxing factor in extracts of blood platelets and its function in the cells. Nature 1963; 198: 488
47 Gross R, Schneider W. Energy metabolism. In Johnson S. A. (ed.) »The circulating platelet«. Academic Press; New York: 1971
48 Hagenfeldt T, Wahren J. Turnover of plasma free arachidonic and oleic acids in resting and exercising human subjects. Metabolism 1975; 24: 799
49 Hamberg M, Samuelsson B. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc. Nat. Acad. Sci. U. S 1973; 70: 899
50 Hamberg M, Samuelsson B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Nat. Acad. Sci. U. S 1974; 71: 3400
51 Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Nat. Acad. Sci. U. S 1975; 72: 2994
52 Haslam R. J. Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser. Haematol VI 1973; 333
53 Haslam R. J. Roles of cyclic nucleotides in platelet function. In »Biochemistry and pharmacology of platelets«. Ciba Foundation Symposium 35 (new series). Elsevier-Excerpta Medica; North-Holland, Amsterdam, Oxford, New York: 1975
54 Haslam R. J, Davidson M. M. L, Fox J. E. B, Lydham J. A. Cyclic nucleotides in platelet function. Thromb. Haemostas 1978; 40: 232
55 Haslam R. J, Davidson M. M. L, Davies T, Lynham J. A, McClenag M. D. Regulation of blood platelet function by cyclic nucleotides. In George W. J, Ignarro L. J. (eds.) »Advances in cyclic nucleotide research«. Raven Press; New York: 9 1978: 533
56 Haslam R. J. Roles of cyclic nucleotides in the inhibition of platelet function by physiological and pharmacological agents. Vllth International Congress on Thrombosis and Haemostasis, London, 1979, Abstr. 200, Thromb. Haemostas 1979; 42: 86
57 Hathaway D. R, Adelstein R. S. Human platelet myosin light chain kinase reguires the calcium-binding protein calmodulin for activity. Proc. Nat. Acad. Sei., U. S 1979; 76: 1655
58 Höfer M. Transport durch biologische Membranen. Das Konzept der Trägerkatalyse. Verl. Chemie, Weinheim; New York: 1977
59 Holmsen H, Day H. J. Adenine nucleotides and platelet function. Ser. Haematol 1971; 4: 28
60 Holmsen H, Day H. J, Setkowsky C. A. Secretory mechanism. Behaviour of adenine nucleotides during the platelet release reaction induced by adenosine diphosphate and adrenaline. Biochem. J 1972; 159: 67
61 Holmsen H. Are platelet shape change aggregation and release reaction tangible manifestations of one basic platelet function?. In Baldini M. G, Ebbe S. (eds.) »Platelets: production, function, transfusion and storage«. Grune & Stratton; New York, San Francisco: 1974
62 Hovig T. The ultrastructural basis of platelet function. In Baldini M. G, Ebbe S. (eds.) »Platelets: production, function, transfusion and storage«. Grune x0026; Stratton; New York, San Francisco: 1974
63 Käser-Glanzmann R, Jakábová M, George J. N, Lüscher E. F. Stimulation of calcium uptake in platelet membrane vesicles by adenosin 3’, 5’-cyclic monophosphate and protein kinase. Biochim. bio-phys. Acta 1977; 466: 429
64 Käser-Glanzmann R, Jákabová M, George J. N, Lüscher E. F. Further characterization of calcium-accumulating vesicles from human bloods platelets. Biochim. bio-phys. Acta 1978; 512: 1
65 Katz A. M, Tada M, Kirchberger M. A. Control of calcium transport in the myocardium by the cycle AMP-protein kinase system. Adv. Cyclic Nucleotide Res 1975; 5: 453
66 Kinlough-Rathbone R. L, Chahil A, Mustard J. F. Effect of calcium and magnesium in the suspending medium on thrombin-induced changes in platelet calcium and magnesium. Amer. J. Physiol 224: 9A1 1973;
67 Kirkpatrick J. P, Mclntire L. V, Moake J. L, Cimo P. L. Differential effects of cytochalasin B on platelet release aggregation and contractility: Evidence against a contractile mechanism for the release of platelet granular contents. Thrombos. Haemostas 1979; 42: 1483
68 Klee C. B, Crouch T. H, Richman P. G. Calmodulin. Ann. Rev. Biochem 1980; 49: 489
69 Kretsinger R. H. The informational role of calcium in the cytosol. Adv. Cycle Nucleotide Res 1979; 11: 1
70 Lapetina E. G, Cuatrecasas P. Stimulation of phosphatidic acid production in platelets precedes the formation of arachi-donate and parallels the release of serotonin. Biochim. biophys. Acta 1979; 573: 394
71 Lapetina E. G, Billah M. M, Cuatrecasas P. Stimulation of the phosphatidylino-sitol-specific phospholipase C and the release of arachidonic acid in activated platelets. In Taylor Mann. (ed.) »The regulation of Coagulation«. Elsevier North-Holland Publ. Comp; New York: 1980
72 Le Breton G. C, Feinberg H. ADP-induced changes in intra platelet Ca²⁺-ion concentration. Pharmacologist 16. 313
73 Le Breton G. C, Dinerstein R. L, Roth L. J, Feinberg H. Direct evidence for intracellular divalent cation redistribution associated with platelet shape change. Bio-chem. biophys. Res. Commun 1976; 71: 362
74 Le Breton G. C, Sandler W. C, Feinberg H. The effect of D₂O and Chlortetracycline on ADP-induced platelet shape change and aggregation. Thromb. Res 1976; 8: 477
75 Le Breton G. C, Dinerstein R. J. Effect of the calcium antagonist TMB-6 on intracellular calcium distribution associated with platelet shape change. Thromb. Res 1977; 10: 521
76 Lehninger A. L, Carafoli E, Rossi C. S. Energy-linked ion movements in mitochondrial systems. Adv. Enzymol 1967; 29: 259
77 Lloyd J. V, Mustard J. F. Changes in ³²P-content of phosphatidic acid and the phos-phoinositides of rabbit platelets during aggregation induced by collagen or thrombin. Brit. J. Haematol 1974; 26: 243
78 Liischer E. F. Viscous metamorphosis of blood platelets and clot retraction. Vox. Sang 1956; 1: 133
79 Liischer E. F. Report of the subcommitee on current concepts of hemostasis. Progress report 1968. Thromb. Diath. Haemorrh 1968; 21: 439
80 Lüscher E. F, Bettex-Galland M. Thrombosthenin the contractile protein of blood platelets, new facts and problems. Path. Biol 1972; 20 Suppl 89
81 Liischer E. F, Probst E, Bettex-Galland M. Thrombosthenin. Structure and function. Ann. N. Y. Acad. Sci 1972; 201: 122
82 Lüscher E. F. Die Funktion der Blutplättchen bei der Thrombose. Schweiz. Akad. med.Wiss; Bull: 29 1973: 165
83 Lüscher E. F, Massini P. Common pathways of membrane reactivity after stimulation of platelets by different agents. In »Biochemistry and pharmacology of platelets«. Ciba Foundation Symposium 35 (new series). Elsevier-Excerpta Medica. North-Holland, Amsterdam; Oxford, New York: 1975
84 Lüscher E. F. Microfilaments in blood platelets. In Heilmeyer L, Rüegg J. C, Wieland Th. (eds.) »Molecular basis of motility«. Springer; Berlin, Heidelberg: 1976
85 Lüscher E. F, Massini P. Die Thrombo-zytenmembran. Schweiz. Akad. med. Wiss; Bull: 32 1976: 161
86 Lüscher E. F. New insights into the structure and function of platelet membranes. In Mills D. C. B, Pareti F. I. (eds.) »Platelets and thrombosis«. Academic Press; London: 1977
87 Lüscher E. F. Calcium-sensitive subcellular structures of the platelet. Proc. 16th Intern. Congr. Hematol., Kyoto, 1976. In: »Topics in Hematology«, Excerpta Medica International Congress Series. Excerpta Medica; Amsterdam: 1977: 415
88 Lüscher E. F. Mechanism of platelet function with particular reference to the effects of drugs acting as inhibitors. Agents Actions 1978; 8: 282
89 Lüscher E. F, Massini P, Käser-Glanzmann R. The role of calcium ions in the regulation of platelet function and their pharmacological control. Advanc. Pharmac. Ther 1978; 4: 87
90 Lüscher E. F, Massini P, Käser-Glanzmann R. The role of calcium ions in the induction of platelet activities. In Rotman A, Meyer F. A, Gitler C, Silberberg A. (eds.) John Wiley and Sons Ltd; Chichester, New York, Brisbrane, Toronto: 1980
91 Macfarlane R. G. Introduction. In Thomas D. (ed.) »Haemostasis«. Brit. Med; Bull: 33 1977: 183
92 Malpass T. W, Harker L. A. Acquired disorders of platelet function. Sem. Hematol 1980; 17: 242
93 Marcus A. J, Ullman H. L, Safier L. B. Lipid composition of subcellular particles of human blood platelets. J. Lipid Res 1969; 10: 108
94 Marguerie G. A, Edington T. S, Plow E. F. Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. J. biol. Chem 1980; 255: 154
95 Massini P, Lüscher E. F. Some effects of ionophores for divalent cations on blood platelets - comparison with the effects of thrombin. Biochim. biophys. Acta 1974; 372: 109
96 Massini P, Lüscher E. F. On the significance of the influx of calciumions into stimulated human blood platelets. Biochim. biophys. Acta 1976; 436: 652
97 Massini P. The role of calcium in the stimulation of platelets. In Mills D. C. B, Pareti F. I. (eds.) »Platelets and thrombosis«. Academic Press; London: 1977
98 Massini P, Käser-Glanzmann R, Lüscher E. F. Movement of calcium ions and their role in the activation of platelets. Thromb. Haemostas 1978; 40: 212
99 Massini P, Näf U. Ca²⁺ionophores and the activation of human blood platelets. The effect of ionomycin, beauvericin, lysocellin, virginiamycin s, lasalocid-derivates and McN, 4308. Biochim biophys. Acta 1980; 598: 575
100 Michell R. H. Inositol phospholipids in membrane function. Trends Biochem. Sci 1979; 4: 128
101 Mills D. C. B. Initial biochemical responses of platelets to stimulation. In: »Biochemistry and pharmacology of platelets«. Ciba Foundation Symposium 35 (new series). Elsevier-Excerpta Medica; North-Holland, Amsterdam, Oxford, New York: 1975
102 Mills D. C. B, Macfarlane D. E. Platelet receptors. In Gordon J. L. (ed.) »Platelets in biology and pathology«. North-Holland Publ. Comp; Amsterdam, New York, Oxford: 1976
103 Moncada S, Vane J. R. Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Brit. med. Bull 1978; 34: 129
104 Moneada S, Vane J. R. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. New Engl. J. Med 1979; 300: 1142
105 Morgenstern E, Kho A. Morphometri-sche Untersuchungen an Blutplättchen: Veränderungen der Plättchenstruktur bei Pseudopodienbildung und Aggregation. Cytobiologie. Eur. J. Cell Biol 1977; 15: 233
106 Morgenstern E, Schneider W. Calcium containing endomembrane system in human platelets during coagulation. Cytobiologie (im Druck)
107 Morgenstern E. Ultracytochemistry of human blood platelets. Progr. Histochem. Cytochem 1980; 12: 1
108 Mürer E. H, Holme R. A study of the release of calcium from human blood platelets and its inhibition by metabolic inhibitors. N-ethylmaleimide and aspirin. Bio-chim. biophys. Acta 1970; 222: 197
109 Mustard J. F, Perry D. W, Kin-lough-Rathbone R. L, Packham M. A. Factors responsible for ADP-induced release of platelet constituents. Amer. J. Physiol 1975; 228: 1757
110 Nugteren D. H, Hazelhof E. Isolation and properties of intermediates in prostaglandin biosynthesis. Biochim. biophys. Acta 1973; 326: 448
111 Packham M. A, Mustard J. F. Clinical pharmacology of platelets. Blood 1977; 50: 555
112 Rapoport S. M. Medizinische Biochemie. VEB Verl. Volk und Gesundheit; Berlin: 1975
113 Rasmussen H, Jensen P, Lake W, Friedman N, Goodman D. B. P. Cyclic Nucleotide Res 1975; 5: 375
114 Rasmussen H, Goodman D. B. P. Relationship between calcium and cyclic nucleotides in cell activation. Physiol. Rev 1977; 57: 421
115 Rebhun L. I. Cyclic nucleotides calcium, and cell division. Int. Rev. Cytol 1977; 49: 1
116 Reimers H. J, Kinglough-Rathbo-ne R. L, Cazenave J. P, Senyi A. F, Hirsh J, Packham M. A, Mustard J. F. In vitro and in vivo functions of thrombin-treated platelets. Thromb. Haemostas 1976; 35: 151
117 Reimers H. J, Packham M. A, Kinlough-Rathbone R. L, Mustard J. F. Adenine nucleotides in thrombin-degranulated platelets: Effect of prolonged circulation in vivo. J. Lab. Clin. Med 1977; 90: 490
118 Reimers H. J. Der Thrombin-stimulierte Thrombozyt. Habil.-Schrift, Med; Fakultät, Univ. Düsseldorf: 1979
119 Reimers H. J. Die Rolle der Thrombozyten in der Pathogenese der Koronarthrom-bose. Hämostaseologie 1981; 1: 13
120 Rittenhouse-Simmons S. Production of diglyceride from phosphatidylinositol in activated human platelets. J. clin. Invest 1979; 63: 580
121 Robblee L. S, Shepro D, Belama-rich F. A. Calcium uptake and associated ade-nosin triphosphatase activity of isolated platelet membranes. J. Gen. Physiol 1973; 61: 462
122 Robblee L. S, Shepro D, Belama-rich F. A, Towle C. Platelet calcium flux and the release reaction. Ser. Haematol 1973; 6: 311
123 Rose B, Loewenstein W. R. Calcium ion distribution in cytoplasma visualized by aequorin: Diffusion in cytosol restricted by energized sequestering. Science 1975; 190: 1204
124 Rotman A, Meyer F. A, Gitler C, Silberberg A. Platelet membrane structure and receptors. In Rotman A, Meyer F. A, Gitler C, Silberberg A. (eds.) Platelets: Cellular response mechanism and their biological significance. John Wiley and Sons Ltd; Chichester, New York, Brisbane, Toronto: 1980: S81-168.
125 Salzman E. W. Cyclic AMP and platelet function. New Engl. J. Med 1972; 286: 358
126 Scharf R. E, Lüscher E. F. The role of mitochondria in the regulation of the cyto-solic calcium levels in human blood platelets. Vllth International Congress on Thrombosis and Haemostasis, London, 1979, Abstr 191. Thrombos. Haemostas 1979; 42: 82
127 Scharf R. E. Calcium. Thrombozyt und Hämostase - Untersuchungen zur Rolle der Plättchenmitochondrien in der Blutstillung. Albert-Knoll-Preisarbeit. Saarl.-Pfalz; Internistenges., Bad Dürk-heim: 1980: 240S
128 Scharf R. E, Lüscher E. F, Azzi A. Calcium uptake by isolated human platelet mitochondria (Manuskript in Vorberei-tung)
129 Schick P. K, Kurica K. B, Chacko G. K. Location of phosphatidylethanolamine and phosphatidylserine in the human platelet membrane. Zit. bei Lüscher, E. F., P. Massini: »Die Thrombozytenmembran«. Bull. Schweiz. Akad. med. Wiss 1976; 32: 161
130 Schmid H. J, Jackson D. P, Conley C. L. Mechanism of action of thrombin on platelets. J. clin. Invest 1962; 11: 543
131 Schneider W. Regulation of energy metabolism in human blood platelets. In Baldini M. G, Ebbe S. (eds.) Platelets: Production, function, transfusion and storage. Grune x0026; Stratton; New York, San Francisco: 1974
132 Schneider W, Gear A. R. L. Significance of glucose and glycogen metabolism for platelet function. In: »Biochemistry and pharmacology of platelets«. Ciba Foundation Symposium 35 (new series). ElsevierExcerpta Medica; North-Holland, Amsterdam, Oxford, New York: 1975
133 Schneider W, Reimers H. J, Morgenstern E. Thrombozytenstoff Wechsel. In Breddin H. K. (ed.) Prostaglandine und Plättchenfunktion. Schattauer; Stuttgart, New York: 1978
134 Simkiss K. Calcium pyrophosphate and cellular pollution. Trends Biochem. Sci 6 (04) III 1981;
135 Skaer R. J. Elemental Composition of platelet dense bodies. In: »Biochemistry and pharmacology of platelets«. Ciba Foundation Symposium 35 (new series). Elsevier-Excerpta Medica; North. Holland, Amsterdam, Oxford, New York: 1975
136 Smith J. B. The prostanoids in hemostasis and thrombosis. Amer. J. Path 1980; 99: 742
137 Statland B. E, Heagan B. M, White J. G. Uptake of calcium by platelet relaxing factor. Nature 1969; 223: 521
138 Steiner M, Tateishi T. Distribution and transport of calcium in human platelets. Biochim. biophys. Acta 1974; 367: 232
139 Stormorken H. The release of secretion: a general basic phenomenon. Scand. J. Haematol: Suppl 1969: 9
140 Sutherland E. W, Rall T. W. The relation of adenosin - 3’5’-phosphate and Phosphorylase to the actions of catecholamines and other hormones. Pharmacol. Rev 1960; 12: 265
141 Taylor D. G, Mapp R. J, Crawford N. The identification of actin associated with pig platelet membranes and granules. Biochem. Soc. Trans 1975; 3: 161
142 Thomas D. (ed.) Haemostasis. Brit. Med. Bull 1977; 33: 183
143 Thomas D. (ed.) Thrombosis. Brit. Med. Bull 1978; 34: 101
144 Vargaftig B. B. Carrageenan and thrombin trigger prostaglandin synthetase-inde-pendent aggregation of rabbit platelets: inhibition by phospholipase A₂inhibitors. J. Pharm. Pharmacol 1977; 29: 222
145 Vargaftig B. B, Chignard M, Benveni-ste J, Le Couedic J. P. One-two, three or more pathways for platelet aggregation. Acta Med. Scand (Suppl) 1980; 642: 23
146 Vickers J. D, Kindlough-Rathbone R. L, Mustard J. F. ADP-induced changes in triphosphatidylinositol of washed rabbit platelets. Circulation 62 Supp (Suppl. 111) 1980; 342
147 Wallach D. F. H, Surgenor D. M, Steel B. B. Calcium-lipid complexes in human platelets. Blood 1958; 13: 589
148 Weisenberg R. Microtubule formation in vitro in solutions containing low calcium concentrations. Science 1972; 177: 1104
149 Werner G, Morgenstern E. Three-dimensional reconstruction of human blood platelets using serial sections. Eur. J. Cell Biol 1980; 20: 276
150 White J. G. Platelet morphology. In Johnson S. A. (ed.) »The circulating platelet«. Academic Press; New York: 1971
151 White J. G. Interaction of membrane systems in blood platelets. Amer. J. Path 1972; 66: 259
152 White J. G, Conard W. J. The fine structure of freeze-fractured blood platelets. Amer. J. Path 1973; 70: 45
153 White J. G. Platelet morphology and function. In Ersley A. J, Rundles R. W. (eds.) »Hematology« McGraw-Hill, Inc; New York, St. Louis, San Francisco: 1977
154 White J. G, Rao G. H. R, Gerrard J. M. Prostaglandins in platelet activation. In Rotman A, Meyer F. A, Gitler C, Silberberg A. (eds.) Platelets: Cellular response mechanism and their biological significance. John Wiley and Sons Ltd; Chichester, New York, Brisbane, Toronto: 1980
155 Young N. J, Crawford N. Isolation from blood platelets and polymorphs of a Ca²⁺-dependent regulator protein (CDR) which activates cyclic nucleotide phosphodiesterase. Thrombos. Haemostas 1979; 42: 81
156 Zucker M. B, Borelli J. Some effects of divalent cations on the clotting mechanism and the platelets of EDTA blood. J. Appl. Physiol 1958; 12: 453
157 Zucker-Franklin D. The submembranous fibrils of human blood platelets. J. Cell. Biol 1970; 47: 293
158 Zucker-Franklin D. Localization of contractile elements. In Cohen L, Lüscher E. F. (eds.) The blood platelet contractile system. Haemostasis: 4 1975: 156
159 Zuzel M. ADP-induced aggregation of blood platelets released from clots by fibrinolysis in vitro. In: Proceedings of the Und Congress of the International Society on Thrombosis and Haemostasis. Oslo, Abstr. 278. 1971

Die Rolle der Kalziumionen bei der Regulation der Thrombozytenfunktion[*]

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Die Rolle der Kalziumionen bei der Regulation der Thrombozytenfunktion^[*]