Download PDF
Thromb Haemost 1979; 42(05): 1620-1625
DOI: 10.1055/s-0038-1657066
Original Article
Schattauer GmbH Stuttgart

The Effect on Thromboelastogram of Normal Blood and Procoagulant Activity of Gel Filtered Uraemic Platelets

Jerzy Umiastowski
The Department of Diagnostic Laboratory and Clinic of Kidney Diseases, Institute of Internal Medicine, Medical Academy, Gdansk, Poland
,
Tadeusz Suchecki
The Department of Diagnostic Laboratory and Clinic of Kidney Diseases, Institute of Internal Medicine, Medical Academy, Gdansk, Poland
› Author Affiliations
Further Information

Publication History

Received 16 March 1979

Accepted 16 January 1980

Publication Date:
18 February 2019 (online)

 PDF Download  Permissions and Reprints

Summary

The effect on thromboeiastogram of normal blood, and activity of platelet factor 3 of gel filtered uraemic platelets were investigated. It was found that gel filtered uraemic platelets cause shortening of “r” time of thromboeiastogram and show increased activity of platelet factor 3 (stypven time). Both phenomena were interpreted as being due to increase of platelet procoagulant activity.

 

  • References

  • 1 Donner L, Neuwirtova R. 1961; The Haemostatic defect of acute and chronic uraemia. Thrombosis et Diathesis Haemorrhagica 5: 391
    PubMedSearch in Google Scholar
  • 2 Heinz JJ, Dolezel G, Lloyd JV, Kinlough-Rathbone RL, Mustard JF. 1974; Platelet factor 3 availability and the platelet release reaction. Journal of Laboratory and Clinical Medicine 84: 474
    PubMedSearch in Google Scholar
  • 3 Horowitz HL, Martinez P, Papayonau MF. 1967; Defective ADP-induced platelet factor 3 activation in uremia. Blood 3: 331
    PubMedSearch in Google Scholar
  • 4 Malanowicz W, Czarniecki W. 1966; Badania thromboelastograficzne w niewydolnosci nerek. Polskie Archiwum Medycyny Wewetrznej 36: 635
    PubMedSearch in Google Scholar
  • 5 Mingers A, Stroder J, Pavel W, Goltner E, Sheitza E. 1969; Gerinnungsparameter vor und nach Peritonealdialyse bei chronischer Ur�mie. Zeitschrift f�r die Gesamte Experimentelle Medizin 150: 101
    PubMedSearch in Google Scholar
  • 6 Rabiner SV, Hrodek O. 1968; Platelet factor 3 in normal subjects and patients with renal failure. Journal of Clinical Investigation 47: 901
    CrossrefPubMedSearch in Google Scholar
  • 7 Suchecki T. 1974; The so-called “onion-like shape thromboelastogram” in dialysed uraemic patients. Thrombosis Et Diathesis Haemorrhagica 31: 513
    PubMedSearch in Google Scholar
  • 8 Tangen O, Berman HJ, Mafrey P. 1971; Gel Filtration. A new technique for separation of blood platelets from plasma Thrombosis et Diathesis Haemorrhagica 25: 268
    PubMedSearch in Google Scholar
  • 9 Webber AJ, Budtz-Olsen OE. 1974; Thrombin stimulated release of platelet microfibrils. British Journal of Haematology 26: 255
    CrossrefPubMedSearch in Google Scholar
  • 10 Winkelmann G, Hörder MH. 1957; Veränderung der Gerinnselhaftfähigkeit durch Leukozyten der myeloischen Reihe. Thromboelastografische Untersuchungen bei chronischen myeloischen Leukämien, akuten Urämien und reaktiven Leukozytosen Acta Haematologica 18: 261
    CrossrefPubMedSearch in Google Scholar