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Thromb Haemost 1982; 48(01): 059-061
DOI: 10.1055/s-0038-1657216
Original Article
Schattauer GmbH Stuttgart

Catabolism of Purified Rat Fibrin(ogen) Plasmin Degradation Products in Rats

W Nieuwenhuizen
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
J J Emeis
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
A Vermond
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 17 March 1982

Accepted 18 May 1982

Publication Date:
13 July 2018 (online)

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Summary

The blood clearance of purified plasmin degradation products (X, Y, D-dimer, Dcate, D EGTA, E-fibrin, Ecate and E EGTA) of rat fibrin(ogen) has been studied in a homologous system. Transcapillary flux rate constants, fractional catabolic rate constants and the ratios of intravascular and extravascular pools have been calculated. There are considerable differences in these constants between the two early fibrinogen degradation products X and Y. Also the differences between fibrinogen D and E fragments, derived from different parts of the fibrinogen molecule, are considerable. However, the differences between fibrin fragment D-dimer and fibrinogen fragment Dcate are relatively small. Also the differences between fragments E-fibrin, Ecate and EEGTA are small. The main fraction of all E-fragments is extravascular.

Keywords

Catabolism in vivo - Rat fibrin(ogen) degradation products - Rat model
 

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