Summary
The blood clearance of purified plasmin degradation products (X, Y, D-dimer, Dcate,
D EGTA, E-fibrin, Ecate and E EGTA) of rat fibrin(ogen) has been studied in a homologous
system. Transcapillary flux rate constants, fractional catabolic rate constants and
the ratios of intravascular and extravascular pools have been calculated. There are
considerable differences in these constants between the two early fibrinogen degradation
products X and Y. Also the differences between fibrinogen D and E fragments, derived
from different parts of the fibrinogen molecule, are considerable. However, the differences
between fibrin fragment D-dimer and fibrinogen fragment Dcate are relatively small.
Also the differences between fragments E-fibrin, Ecate and EEGTA are small. The main
fraction of all E-fragments is extravascular.
Keywords
Catabolism in vivo - Rat fibrin(ogen) degradation products - Rat model