Catabolism of Purified Rat Fibrin(ogen) Plasmin Degradation Products in Rats

W Nieuwenhuizen; J J Emeis; A Vermond

doi:10.1055/s-0038-1657216

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1982; 48(01): 059-061
DOI: 10.1055/s-0038-1657216

Original Article

Schattauer GmbH Stuttgart

Catabolism of Purified Rat Fibrin(ogen) Plasmin Degradation Products in Rats

W Nieuwenhuizen

The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands

,

J J Emeis

The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands

,

A Vermond

The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands

› Author Affiliations

Abstract

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Summary

The blood clearance of purified plasmin degradation products (X, Y, D-dimer, Dcate, D EGTA, E-fibrin, Ecate and E EGTA) of rat fibrin(ogen) has been studied in a homologous system. Transcapillary flux rate constants, fractional catabolic rate constants and the ratios of intravascular and extravascular pools have been calculated. There are considerable differences in these constants between the two early fibrinogen degradation products X and Y. Also the differences between fibrinogen D and E fragments, derived from different parts of the fibrinogen molecule, are considerable. However, the differences between fibrin fragment D-dimer and fibrinogen fragment Dcate are relatively small. Also the differences between fragments E-fibrin, Ecate and EEGTA are small. The main fraction of all E-fragments is extravascular.

Keywords

Catabolism in vivo - Rat fibrin(ogen) degradation products - Rat model

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References

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