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Thromb Haemost 1982; 48(02): 235-237
DOI: 10.1055/s-0038-1657264
Original Article
Schattauer GmbH Stuttgart

Effect of Vitamin E on Endotoxin-Induced Disseminated Intravascular Coagulation in Rats

T Yoshikawa
The First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
Y Furukawa
The First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
M Murakami
The First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
K Watanabe
The First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
,
M Kondo
The First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
› Author Affiliations
Further Information

Publication History

Received 25 June 1982

Accepted 30 July 1982

Publication Date:
13 July 2018 (online)

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Summary

Experimental disseminated intravascular coagulation (DIC) can be induced by 4 hr sustained infusion of endotoxin in a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of vitamin E, α-tocopheryl acetate, against DIC. Before the infusion of endotoxin, 0.01, 0.1, 1.0 or 10.0 mg/kg/day of α-tocopheryl acetate was injected intraperitoneally for 4 successive days. The preventive effect against DIC was noted in all the parameters, such as fibrinogen and fibrin degradation products, fibrinogen level, prothrombin time, partial thromboplastin time, platelet count, and the number of renal glomeruli with fibrin thrombi, in rats treated with 1.0 or 10.0 mg/kg of α-tocopheryl acetate. From these results, it was shown that vitamin E, α-tocopheryl acetate, inhibited endotoxin-induced experimental DIC in rats.

Keywords

DIC - Endotoxin - α-tocopheryl acetate - Rat
 

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