Thromb Haemost 1983; 49(02): 106-108
DOI: 10.1055/s-0038-1657332
Original Article
Schattauer GmbH Stuttgart

Reduction of Gastric Haemorrhage by Fibrinolysis Inhibition – An Experimental Study in Rats

Björn Stenberg
The Department of Surgery I, Sahlgrenska sjukhuset, University of Göteborg, Göteborg, Sweden
,
Lilian Karlsson
The Department of Surgery I, Sahlgrenska sjukhuset, University of Göteborg, Göteborg, Sweden
,
Magne Alpsten
*   The Department of Radiation Physics, Sahlgrenska sjukhuset, University of Göteborg, Göteborg, Sweden
,
Bo Risberg
The Department of Surgery I, Sahlgrenska sjukhuset, University of Göteborg, Göteborg, Sweden
› Author Affiliations
Further Information

Publication History

Received 02 December 1982

Accepted 27 January 1983

Publication Date:
18 July 2018 (online)

Summary

Gastric ulcerations were induced in rats by pyloric ligature and instillation of 1.0 N HCl. After four hours all rats had developed ulcerations. Increased release of plasminogen activators from the mucosa during these conditions has previously been demonstrated. In the present study we investigated the role of fibrinolysis inhibition versus Hz-receptor blockade on the gastric bleeding. Tranexamic acid – a synthetic inhibitor of the fibrinolytic system – was found to significantly (p <0.01) reduce blood loss into the gastric juice by 30% measured by 51Cr labelled red blood cells; cimetidine did not reduce the gastric haemorrhage under the experimental conditions used. Both treatment regimes significantly (p <0.02) reduced the secretion of gastric juice. These results indicate a contribution of the fibrinolytic system in gastric bleeding from experimentally induced gastric ulcerations.

 
  • References

  • 1 Cormack F, Chakrabarti RR, Jouhar AJ, Feamley GR. Tranexamic acid in upper gastrointestinal haemorrhage. Lancet 1973; 1: 1207-1208
  • 2 Biggs JC, Hugh TB, Dodds AJ. Tranexamic acid and upper gastrointestinal haemorrhage – a double blind trial. Gut 1976; 17: 729-734
  • 3 Engqvist A, Broström O, von FeilitzenF, Hallin M, Nyström B, Ŏst Å, Reichard H, Sandquist S, Törngren S, Wedlund JE. Tranexamic acid in massive haemorrhage from the upper gastrointestinal tract. A double-blind study. Scand J Gastroenterol 1979; 14: 839-844
  • 4 Way LW. Upper gastrointestinal haemorrhage. In: Dunphy JE, Way LE. (eds). Current surgical diagnosis and treatment. Los Altos Lange year to follow on galley proof p. 482
  • 5 Nilsson IM, Bergentz SE, Wiklander O, Hedner U. Erosive haemorrhagic gastroduodenitis with fibrinolysis and low factor XIII. Ann Surg 1975; 182: 677-682
  • 6 Buhr HJ, Encke A, Seufert RM. Untersuchungen zur lokalen Fibrinolyse des Magens. Chirurg 1978; 49: 431-435
  • 7 Stenberg B, Risberg B, Hedman L, Peterson H-I. Tissue fibrinolysis in experimental gastric ulcer – a study in the rat. Eur J Clin Invest 1981; 11: 361-367
  • 8 Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet SA. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945; 5: 43-61
  • 9 Stenberg B, Risberg B, Peterson HI. Tranexamic acid and gastric fibrinolysis in the rat. Thromb Haemostas 1980; 42: 1425-1428
  • 10 Owen DAA, Parsons ME, Farrington HE, Blakemore R. Reduction of cimetidine of acute gastric haemorrhage caused by reinfusion of blood after exposure to exogenous acid during gastric ischemia in rats. Gastroenterology 1979; 77: 979-985
  • 11 Stenberg B, Risberg B, Zettergren L, Peterson HI. Localization of tissue fibrinolysis in the gastrointestinal tract. Thromb Haemostas 1980; 42: 1417-1424
  • 12 Kondo M, Bamba T, Hosokawa K, Hosoda S, Kawai K, Masuda M. Tissue plasminogen activator in the pathogenesis of protein-loosing gastroenteropathy. Gastroenterology 1976; 70: 1045-1047
  • 13 Cox HT, Poller L, Thomson JM. Gastric fibrinolysis. A possible aetiological link with peptic ulcer. Lancet 1967; 1: 1300-1302
  • 14 Cox HT, Poller L, Thomson JM. Evidence for the release of gastric fibrinolytic activity into peripheral blood. Gut 1969; 10: 404-407
  • 15 Thomson JM. Fibrinolysis and the stomach – Biochemical identification of the “plasmin-like” enzyme. Thrombos Diathes Haemorrh 1974; 31: 291-298
  • 16 O’Brien TE, Hadley H, Irving MH. Fibrinolytic activity in gastric venous blood. Gastroenterology 1979; a 76: 509-514
  • 17 Eras P, Harpel P, Winawer SJ. Histological localization of plasminogen activator and proteolytic activity in human stomach and duodenum. Gut 1970; 11: 851-854
  • 18 Kondo M, Ikezaki M, Imanishi H, Nishigaki I, Nakai T, Hosokawa K. Role of tissue fibrinolytic activity in gastroduodenal ulcer. Journal of the Kyoto Prefectural University of Medicine 1975; 84: 1021-1027