Pathophysiology of Platelet Thrombin Receptors

• References

• 1 Jamieson GA. The activation of platelets by thrombin: A model for activation by high and moderate affinity receptor pathways. In: Jamieson GA. ed Platelet Membrane Receptors: Molecular Biology, Immunology, Biochemistry, and Pathology. New York: Alan R. Liss, Inc.; 1988: 137-158
• 2 Greco NJ, Jamieson GA. High and moderate affinity pathways for α-thrombin-induced platelet activation. Proc Soc Exp Biol Med 1991; 198: 792-799
• 3 Harmon JT, Jamieson GA. Thrombin binds to a high-affinity ∼900,000 dal ton site on human platelets. Biochemistry 1985; 24: 58-64
• 4 DeMarco L, Mazzucato M, Masotti A, Fenton JW, Ruggeri ZM. Function of glycoprotein lb alpha in platelet activation induced by alph α-thrombin. J Biol Chem 1991; 266: 23776-23783
• 5 Gralnick HR, Williams S, McKeown LP, Hansmann K, Fenton III JW, Krutzsch H. High-affinity α-thrombin binding to platelet glycoprotein Ibα: Identification of two binding domains. Proc Natl Acad Sci USA 1994; 91: 6334-6338
• 6 Greco NJ, Tenner Jr TE, Tandon NN, Jamieson GA. PPACK-thrombin inhibits thrombin-induced platelet aggregation and cytoplasmic acidification but does not inhibit platelet shape change. Blood 1990; 75: 1983-1990
• 7 Greco NJ, Tandon NN, Jamieson GA. Thrombin binding to platelets defines functional receptors: Inhibition of thrombin- induced platelet activation by catalytically-inactivated thrombin. Platelets 1995; 06: 270-274
• 8 Mazurov AV, Vinogradov DV, Vlasik TN, Repin VS, Booth WJ, Berndt MC. Characterization of an antiglycoprotein lb monoclonal antibody that specifically inhibits platelet-thrombin interaction. Thromb Res 1991; 62: 673-684
• 9 Greco NJ, Tandon NN, Jones GD. et al Contributions of glycoprotein lb and the seven transmembrane domain receptor to increases in platelet cytoplasmic [Ca²⁺]_iinduced by α-thrombin. Biochemistry 1996; 35: 906-914
• 10 Peng M, Emig FA, Mao A. et al Interaction of echicetin with a high affinity thrombin binding site on platelet glycoprotein GPIb. Thromb Haemost 1995; 74: 954-957
• 11 McNicol A, Sutherland M, Zou r, Drouin J. Defective thrombin- induced calcium changes and aggregation of Bernard-Soulier platelets are not associated with deficient moderate-affinity receptors. Arterioscler Thromb & Vascular Biol 1996; 16: 628-632
• 12 Harmon JT, Jamieson GA. Activation of platelets by alpha-thrombin is a receptor-mediated event. J Biol Chem 1986; 261: 15928-15933
• 13 Brower MS, Levin RI, Garry K. Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins. J Clin Invest 1985; 75: 657-666
• 14 Greco NJ, Jones GD, Tandon NN, Kornhauser R, Jackson B, Jamieson GA. Differentiation of the two forms of GPIb functioning as receptors for α-thrombin and von Willebrand factor: Ca²⁺responses of protease-treated human platelets activated with α-thrombin and the tethered ligand peptide. Biochemistry 1996; 35: 915-921
• 15 Lopez JA. The platelet glycoprotein Ib-IX complex. Blood Coagul Fibrinolysis 1994; 05: 97-119
• 16 Parry MAA, Stone SR, Hofsteenge J, Jackman MP. Evidence for common structural changes in thrombin induced by active-site or exosite binding. Biochem J 1993; 290: 665-670
• 17 Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A. The isomorphous structures of prethrombin2, hirugen-, and PPACK- thrombin: Changes accompanying activation and exosite binding to thrombin. Protein Sci 1994; 03: 2254-2271
• 18 Wu Q, Sheehan JP, Tsiang M, Lentz SR, Birktoft JJ, Sadler JE. Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin. Proc Natl Acad Sci USA 1991; 88: 6775-6779
• 19 Okumura T, Jamieson GA. A single receptor for platelet aggregation induced by thrombin or ristocetin. Thromb Res 1976; 08: 701-706
• 20 DeMarco L, Mazzucato M, Masotti A, Ruggeri ZM. Localization and characterization of an a-thrombin-binding site on platelet glycoprotein Iba. J Biol Chem 1994; 269: 6478-6484
• 21 Ward CM, Andrews RK, Smith AI, Bemdt MC. Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibα. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Iba as a binding site for von Willebrand factor and a-thrombin. Biochemistry 1996; 35: 4929-4938
• 22 Marchese P, Murata M, Mazzucato M. et al Identification of three tyrosine residues of glycoprotein Ibα with distinct roles in von Willebrand factor and a-thrombin binding. J Biol Chem 1995; 16: 9571-9578
• 23 Dong J-F, Li CQ, Lopez JA. Tyrosine sulfation of the glycoprotein Ib-IX complex: Identification of sulfated residues and effect on ligand binding. Biochemistry 1994; 33: 13946-13953
• 24 Wyler B, Bienz D, Clemetson KJ, Luscher EF. Glycoprotein Ibα is the only phosphorylated major membrane glycoprotein in human platelets. Biochem J 1986; 234: 373-379
• 25 Vu T-KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
• 26 Rasmussen UB, Vouret-Craviari V, Jallat S. et al: cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca²⁺mobilization. FEBS Lett 1991; 288: 123-128
• 27 Brass LF, Vassallo Jr RR, Belmonte E, Ahuja M, Cichowski K, Hoxie JA. Structure and function of the human platelet thrombin receptor. J Biol Chem 1992; 267: 13795-13798
• 28 Lau L-F, Pumiglia K, Cote YP, Feinstein MB. Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators. Biochem J 1994; 303: 391-400
• 29 Kramer RM, Roberts EF, Hyslop PA, Utterback BG, Hui KY, Jakubowski JA. Differential activation of cytosolic phospholipase A₂(cPLA₂) by thrombin and thrombin receptor agonist peptide in human platelets. J Biol Chem 1995; 270: 14816-14823
• 30 Goodwin CA, Wheeler-Jones CPD, Kakkar VV, Deadman JJ, Authi KS, Scully MF. Thrombin receptor activating peptide does not stimulate platelet procoagulant activity. Biochem Biophys Res Commun 1994; 202: 321-327
• 31 Sugama Y, Tiruppathi CM, Janakidevi K, Andersen TT, Fenton II JW, Main AB. Thrombin-induced expression of endothelial P-Selectin and intercellular adhesion molecule-1: A mechanism for stabilizing neutrophil adhesion. J Cell Biol 1992; 119: 935-944
• 32 Lum H, Andersen TT, Siflinger-Birnboim A. et al: Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization. J Cell Biol 1993; 120: 1491-1499
• 33 Lenormand P, Sardet C, Pages G, L’Alleman G, Brunet A, Pouyssegur J. Growth factors induce nuclear translocation of MAP kinases (p42^mapkand p44^mapk) but not of their activator MAP kinase kinase (p45^mapkk) in fibroblasts. J Cell Biol 1993; 122: 1079-1088
• 34 Vouret-Craviari V, Van Obberghen-SchillingE, Scimeca JC, Van ObberghenE, Pouyssegur J. Differential activation of p44 ^mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist. Biochem J 1993; 289: 209-214
• 35 Jenkins AL, Bootman MD, Derridge MJ, Stone SR. Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells. J Biol Chem 1994; 269: 17104-17110
• 36 Connolly AJ, Ishihara H, Kahn ML, Farese Jr RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996; 381: 516-519
• 37 Darrow AL, Fung-Leung W-P, Ye RD. et al: Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost 1996; 76: 860-866
• 38 Seiler SM, Michel IM, Fenton JW. Involvement of the “tethered-ligand” receptor in thrombin inhibition of platelet adenylate cyclase. Biochem Biophys Res Commun 1992; 182: 1296-1302
• 39 Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem 1994; 269: 8483-8487
• 40 Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC. Association of a phospholipase A₂(14-3-3 protein) with the platelet glycoprotein Ib-IX complex. J Biol Chem 1994; 269: 18287-18290
• 41 Ishii K, Chen J, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. J Biol Chem 1994; 269: 1125-1130
• 42 Hung DT, Vu T-KH, Nelken NA, Coughlin SR. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest 1992; 89: 1350-1353
• 43 Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. J Biol Chem 1993; 268: 9780-9786
• 44 Shuman MA, Levine SP. Thrombin generation and secretion of platelet factor 4 during blood clotting. J Clin Invest 1978; 61: 1102-1106
• 45 Wewer UM, Liotta LA, Jaye M. et al: Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to binding laminin. Proc Natl Acad Sci USA 1986; 83: 7137-7141
• 46 Smalheiser NR, Schwartz NB. Cranin: A laminin-binding protein of cell membranes. Proc Natl Acad Sci USA 1987; 84: 6457-6461
• 47 Terranova VP, Rao CN, Kalebic T, Margulies IM, Liotta LA. Laminin receptor on human breast carcinoma cells. Proc Natl Acad Sci USA 1983; 80: 444-448
• 48 Liu L, Freedman J, Hornstein A, Fenton II JW, Song Y, Ofosu FA. Binding of thrombin to the G-protein-linked receptor, and not to glycoprotein lb, precedes thrombin-mediated platelet activation. J Biol Chem 1997; 272: 1997-2004
• 49 From an address at the inauguration of the Faculty of Science of the University of Lille. 07..1854. in R. ValleryRadotLa Vie de Pasteur(1900) Ch. 4