A Multivariate Pattern Recognition Study of Risk-Factors Indicating Postoperative Thromboembolism Despite Low-Dose Heparin in Major Abdominal Surgery

J Kjærgaard; K Esbensen; P Wille-Jørgensen; T Jørgensen; J Thorup; H Berning; S Wold

doi:10.1055/s-0038-1657750

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 54(02): 409-412
DOI: 10.1055/s-0038-1657750

Original Article

Schattauer GmbH Stuttgart

A Multivariate Pattern Recognition Study of Risk-Factors Indicating Postoperative Thromboembolism Despite Low-Dose Heparin in Major Abdominal Surgery

J Kjærgaard

^*The Department of Surgical Gastroenterology, University of Copenhagen, Denmark

,

K Esbensen

^**The Norwegian Computing Center, Oslo, Norway

,

P Wille-Jørgensen

^*The Department of Surgical Gastroenterology, University of Copenhagen, Denmark

,

T Jørgensen

^*The Department of Surgical Gastroenterology, University of Copenhagen, Denmark

,

J Thorup

^*The Department of Surgical Gastroenterology, University of Copenhagen, Denmark

,

H Berning

^***The Department of Clinical Chemistry, Herlev Hospital, University of Copenhagen, Denmark

,

S Wold

^****The Chemometric Research Group, University of Umeå, Sweden

› Author Affiliations

Abstract

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Summary

The object of the present investigation was to identify those who, among high-risk patients, would “break through” low-dose heparin prophylaxis and develop thromboembolism after major abdominal surgery.

Twenty-nine variables (clinical characteristics, pre- and postoperative coagulation and fibrinolytic factors) from 19 patients with and 26 patients without thromboembolism were analyzed by means of a multivariate supervised pattern recognition technique (SIMCA).

We found no statistically significant difference between patients with and without thromboembolism. Thus, in the studied group of high-risk patients it was not possible to identify a predictive index for selection of individual patients liable to develop postoperative thromboembolism despite low-dose heparin prophylaxis in major abdominal surgery.

Keywords

Heparin prophylaxis - Major abdominal surgery - Risk factors - Multivariate analysis

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References

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